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Home / Proteins & Peptide

Recombinant Human Voltage-gated potassium channel subunit beta-2(KCNAB2)

SKU : BHP10500667

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CUSABIO TECHONOLOGY LLC

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Mfr.No.	CSB-EP012014HU
Alternative Names	K(+) channel subunit beta-2Kv-beta-2 ,hKvbeta2, K(+) channel subunit beta-2Kv-beta-2 ; hKvbeta2
Antigen	KCNAB2
Tag	N-terminal 6xHis-SUMO-tagged
Regulatory	RUO
Relevance	Cytoplasmic domain potassium channel subunit that modulates the characteristics of the channel-forming alpha-subunits . Contributes to the regulation of nerve signaling, and prevents neuronal hyperexcitability . Promotes expression of the pore-forming alpha subunits at the cell mbrane, and thereby increases channel activity . Promotes potassium channel closure via a mechanism that does not involve physical obstruction of the channel pore . Promotes KCNA4 channel closure . Modulates the functional properties of KCNA5 . Enhances KCNB2 channel activity . Binds NADPH and has NADPH-dependent aldoketoreductase activity . Has broad substrate specificity and can catalyze the reduction of methylglyoxal, 9,10-phenanthrenequinone, prostaglandin J2, 4-nitrobenzaldehyde, 4-nitroacetophenone and 4-oxo-trans-2-nonenal (in vitro) .
Source	E.coli
Notes	Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Expression Region	1-367aa
Mol Weight	57.0kDa
Nature	recombinant
Protein Description	Full Length

Subcellular Location	Cytoplasm, Membrane, Peripheral membrane protein, Cytoplasmic side, Cell membrane, Peripheral membrane protein, Cytoplasmic side, Cell projection, axon, Cell junction, synapse, synaptosome, Cytoplasm, cytoskeleton
Uniprot	Q13303, Q13303
Database Links	HGNC:6229 OMIM:601142 KEGG:hsa:8514 STRING:9606.ENSP00000367323 UniGene:Hs.440497
Function	Cytoplasmic potassium channel subunit that modulates the characteristics of the channel-forming alpha-subunits
Protein Families	Shaker potassium channel beta subunit family
Research Area	Neuroscience
Tissue Specificity	Detected in myelinated nerve fibers in the spinal cord, in the juxtaparanodal region of the nodes of Ranvier, but also in the paranodal region (PubMed:11086297). Detected in hippocampus (at protein level) (PubMed:21357749). Detected in hippocampus (PubMed
Weight	56.97kDa

Stotage Note	Repeated freezing and thawing is not recommended. Store working aliquots at 4℃ for up to one week.
Buffer	Tris-based buffer，50% glycerol
Purity	Greater than 90% as determined by SDS-PAGE.
Storage	The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Storage Buffer	Tris-based buffer,50% glycerol

Immunogen Species	Homo Sapiens (Human)

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SKU	Supplier No.	Size	Your price	Quantity
BHP10500667	CSB-EP012014HU	1mg	$1812		Add to Cart
BHP10500667	CSB-EP012014HU	100ug	$419		Add to Cart
BHP10500667	CSB-EP012014HU	20ug	$224		Add to Cart

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