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Recombinant Human Very long-chain acyl-CoA synthetase(SLC27A2),partial

SKU : BHP10502483

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CUSABIO TECHONOLOGY LLC

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Mfr.No.	CSB-YP021534HU
Alternative Names	Fatty acid transport protein 2 ,FATP-2Fatty-acid-coenzyme A ligase, very long-chain 1Long-chain-fatty-acid--CoA ligase (EC:6.2.1.3)Solute carrier family 27 member 2THCA-CoA ligaseVery long-chain-fatty-acid-CoA ligase, Fatty acid transport protein 2 ; FATP-2Fatty-acid-coenzyme A ligase, very long-chain 1Long-chain-fatty-acid--CoA ligase (EC:6.2.1.3)Solute carrier family 27 member 2THCA-CoA ligaseVery long-chain-fatty-acid-CoA ligase
Tag	N-terminal 6xHis-tagged
Regulatory	RUO
Relevance	Acyl-CoA synthetase probably involved in bile acid metabolism. Proposed to activate C27 precurors of bile acids to their CoA thioesters derivatives before side chain cleavage via peroxisomal beta-oxidation occurs. In vitro, activates 3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholestanate (THCA), the C27 precursor of cholic acid deriving from the de novo synthesis from cholesterol. Does not utilize C24 bile acids as substrates. In vitro, also activates long- and branched-chain fatty acids and may have additional roles in fatty acid metabolism. May be involved in translocation of long-chain fatty acids (LFCA) across mbranes .
Source	Yeast
Notes	Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Protein Name	Recommended name: Very long-chain acyl-CoA synthetase Short name= VLACS Short name= VLCS EC= 6.2.1.-Alteative name(s): Fatty acid transport protein 2 Short name= FATP-2 Fatty-acid-coenzyme A ligase, very long-chain 1
Expression Region	283-620aa
Mol Weight	40.8kDa
Nature	recombinant
Protein Description	Partial

Subcellular Location	Endoplasmic reticulum membrane, Multi-pass membrane protein, Peroxisome membrane, Multi-pass membrane protein
Uniprot	O14975, O14975
Database Links	HGNC:10996 OMIM:603247 KEGG:hsa:11001 STRING:9606.ENSP00000267842 UniGene:Hs.11729
Function	Acyl-CoA synthetase probably involved in bile acid metabolism. Proposed to activate C27 precursors of bile acids to their CoA thioesters derivatives before side chain cleavage via peroxisomal beta-oxidation occurs. In vitro, activates 3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholestanate (THCA), the C27 precursor of cholic acid deriving from the de novo synthesis from cholesterol. Does not utilize C24 bile acids as substrates. In vitro, also activates long- and branched-chain fatty acids and may have additional roles in fatty acid metabolism. May be involved in translocation of long-chain fatty acids (LFCA) across membranes (By similarity).
Pathway	PPAR signaling pathway
Protein Families	ATP-dependent AMP-binding enzyme family
Research Area	Metabolism
Tissue Specificity	Expressed in liver, kidney, placenta and pancreas.
Weight	40.8kDa

Stotage Note	Repeated freezing and thawing is not recommended. Store working aliquots at 4℃ for up to one week.
Buffer	Tris-based buffer，50% glycerol
Purity	Greater than 90% as determined by SDS-PAGE.
Storage	The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Storage Buffer	Tris-based buffer,50% glycerol

Immunogen Species	Homo Sapiens (Human)

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SKU	Supplier No.	Size	Your price	Quantity
BHP10502483	CSB-YP021534HU	500ug	$1298		Add to Cart
BHP10502483	CSB-YP021534HU	100ug	$470		Add to Cart
BHP10502483	CSB-YP021534HU	20ug	$250		Add to Cart

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