UP1 is a non-glycosylated secretoglobin family member protein which induces anti-inflammatory and anti-tumorigenic responses. The expression of Uteroglobin is induced by steroid hormones such as estrogen which is further enhanced by the non-steroid hormone prolactin. UP1 has been shown to induce growth stimulatory effects, sequester pro-inflammatory mediators and carcinogens and inhibit cell migration, cell invasion, platelet aggregation and T cell differentiation.
Alternative Names
Clara cell phospholipid-binding protein ; CCPBP ; Clara cells 10 kDa secretory protein ; CC10 ; Secretoglobin family 1A member 1 ; Urinary protein 1 ; Urine protein 1 ; UP1
Quantity
100 µg
Regulatory
RUO
Source
E. coli
Host
Human
Endotoxin Level
< 1.0 EU/μg of recombinant protein as determined by the LAL method.
Biological Activity Comment
N.A.
Weight
8.2 kDa
Description
Reconstitute at 100 μg/mL in sterile PBS
Format
Lyophilized PowderLyophilized from a 0.2 μm filtered solution in PBS
Purity
>95% as determined by SDS-PAGE
Storage
The lyophilized protein is stable for at least one year from date of receipt at -70°C. Upon reconstitution, this cytokine can be stored in working aliquots at 2° - 8°C for one month, or at -20°C for six months, with a carrier protein without detectable loss of activity.