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Home / Proteins & Peptide

Recombinant Human Uracil-DNA glycosylase/UNG Protein (GST Tag)

SKU : BHP10302810

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Elabscience Biotechnology Co.,Ltd

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Mfr.No.	PKSH030766
Description	A DNA sequence encoding the human UNG isoform 1 (P13051-2) (Phe 85-Leu 304) was fused with the GST tag at the N-terminus.
Alternative Names	DGU;HIGM4;HIGM5;UDG;UNG1;UNG15;UNG2
Reconstitution	Please refer to the printed manual for detailed information.
Background	Isoform 1 is widely expressed with the highest expression in skeletal muscle, heart and testicles. Isoform 2 has the highest expression levels in tissues containing proliferating cells. Uracil-DNA glycosylase exists in two forms: mitochondrial uracil-DNA glycosylase 1 (UNG1) and nuclear uracil-DNA glycosylase 2 (UNG2). uracil-DNA glycosylase. This gene encodes one of several uracil-DNA glycosylases. One important function of uracil-DNA glycosylases is to prevent mutagenesis by eliminating uracil from DNA molecules by cleaving the N-glycosylic bond and initiating the base-excision repair (BER) pathway. Uracil bases occur from cytosine deamination or misincorporation of dUMP residues. Alternative promoter usage and splicing of this gene leads to two different isoforms: the mitochondrial UNG1 and the nuclear UNG2. The UNG2 term was used as a previous symbol for the CCNO gene (GeneID 10309), which has been confused with this gene, in the literature and some databases. Defects in UNG are a cause of immunodeficiency with hyper-IgM type 5 (HIGM5). A rare immunodeficiency syndrome characterized by normal or elevated serum IgM levels with absence of IgG, IgA, and IgE. It results in a profound susceptibility to bacterial infections.
Reactivity	Human
Tag	N-GST
Formulation	Lyophilized from sterile 40mM Tris, 0.15M NaCl, 2mM GSH, pH 7.5
Host	E.coli
Accession Number	P13051-2
Endotoxin Level	Please contact us for more information.
Mol Weight	52 kDa
Mw(kda)	52 kDa

Sequence Info	Phe 85-Leu 304

Shipping	This product is provided as lyophilized powder which is shipped with ice packs.
Stotage Note	Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
Purity	> 90 % as determined by reducing SDS-PAGE.

Product Manual	Data Sheet

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SKU	Supplier No.	Size	Your price	Quantity
BHP10302810	PKSH030766	100ug	$855		Add to Cart

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