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Home / Proteins & Peptide

Recombinant Human Unconventional myosin-VIIa(MYO7A),partial

SKU : BHP10503252

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CUSABIO TECHONOLOGY LLC

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Mfr.No.	CSB-EP622657HU
Tag	N-terminal 6xHis-SUMO-tagged
Regulatory	RUO
Relevance	Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Their highly divergent tails bind to membranous compartments, which are then moved relative to actin filaments. In the retina, plays an important role in the renewal of the outer photoreceptor disks. Plays an important role in the distribution and migration of retinal pigment epithelial (RPE) melanosomes and phagosomes, and in the regulation of opsin transport in retinal photoreceptors. In the inner ear, plays an important role in differentiation, morphogenesis and organization of cochlear hair cell bundles. Involved in hair-cell vesicle trafficking of aminoglycosides, which are known to induce ototoxicity (By similarity). Motor protein that is a part of the functional network formed by USH1C, USH1G, CDH23 and MYO7A that mediates mechanotransduction in cochlear hair cells. Required for normal hearing.
Source	E.coli
Abbreviation	MYO7A
Notes	Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Protein Name	Recommended name: Unconventional myosin-VIIa
Expression Region	838-968aa
Mol Weight	31.3kDa
Nature	recombinant
Protein Description	Partial

Involvement In Disease	Usher syndrome 1B (USH1B); Deafness, autosomal recessive, 2 (DFNB2); Deafness, autosomal dominant, 11 (DFNA11)
Subcellular Location	Cytoplasm, Cytoplasm, cell cortex, Cytoplasm, cytoskeleton
Uniprot	Q13402, Q13402
Database Links	HGNC:7606 OMIM:276900 KEGG:hsa:4647 STRING:9606.ENSP00000386331 UniGene:Hs.370421
Function	Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Their highly divergent tails bind to membranous compartments, which are then moved relative to actin filaments. In the retina, plays an important role in the renewal of the outer photoreceptor disks. Plays an important role in the distribution and migration of retinal pigment epithelial (RPE) melanosomes and phagosomes, and in the regulation of opsin transport in retinal photoreceptors. In the inner ear, plays an important role in differentiation, morphogenesis and organization of cochlear hair cell bundles. Involved in hair-cell vesicle trafficking of aminoglycosides, which are known to induce ototoxicity (By similarity). Motor protein that is a part of the functional network formed by USH1C, USH1G, CDH23 and MYO7A that mediates mechanotransduction in cochlear hair cells. Required for normal hearing.
Protein Families	TRAFAC class myosin-kinesin ATPase superfamily, Myosin family
Research Area	Signal Transduction
Tissue Specificity	Expressed in the pigment epithelium and the photoreceptor cells of the retina. Also found in kidney, liver, testis, cochlea, lymphocytes. Not expressed in brain.
Weight	31.32kDa

Stotage Note	Repeated freezing and thawing is not recommended. Store working aliquots at 4℃ for up to one week.
Buffer	Tris-based buffer，50% glycerol
Purity	Greater than 90% as determined by SDS-PAGE.
Storage	The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Storage Buffer	Tris-based buffer,50% glycerol

Immunogen Species	Homo Sapiens (Human)

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SKU	Supplier No.	Size	Your price	Quantity
BHP10503252	CSB-EP622657HU	1mg	$2466		Add to Cart
BHP10503252	CSB-EP622657HU	100ug	$578		Add to Cart
BHP10503252	CSB-EP622657HU	20ug	$306		Add to Cart

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