A DNA sequence encoding the human ULBP2 (Q9BZM5) (Met 1-Ser 217);without the pro peptide; w was fused with the Fc region of human IgG1 at the C-terminus.
Alternative Names
NKG2D Ligand 2; N2DL-2; NKG2DL2; ALCAN-Alpha; Retinoic Acid Early Transcript 1H; UL16-Binding Protein 2; ULBP2; N2DL2; RAET1H
Reconstitution
Please refer to the printed manual for detailed information.
Background
NKG2D ligand 2; also known as N2DL-2; NKG2DL2; ALCAN-alpha; Retinoic acid early transcript 1H; UL16-binding protein 2; ULBP2 and N2DL2; is cell membrane protein which belongs to the MHC class I family. ULBP2 / N2DL-2 is expressed in various types of cancer cell lines and in the fetus; but not in normal tissues. ULBP2 / N2DL-2 is a ligand for the NKG2D receptor; together with at least ULBP1 and ULBP3. ULBPs activate multiple signaling pathways in primary NK cells; resulting in the production of cytokines and chemokines. Binding of ULBPs ligands to NKG2D induces calcium mobilization and activation of the JAK2; STAT5; ERK and PI3K kinase/Akt signal transduction pathway.
Reactivity
Human
Tag
C-Fc
Formulation
Lyophilized from sterile PBS; pH 7.4
Host
HEK293 Cells
Accession Number
Q9BZM5
Endotoxin Level
< 1.0 EU per ug as determined by the LAL method.
Mol Weight
48.7 kDa
Mw(kda)
48.7 kDa
Sequence Info
Met 1-Ser 217
Shipping
This product is provided as lyophilized powder which is shipped with ice packs.
Stotage Note
Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.