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Home / Proteins & Peptide

Recombinant Human Ubiquitin-conjugating enzyme E2 K(UBE2K)

SKU : BHP10501954

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CUSABIO TECHONOLOGY LLC

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Mfr.No.	CSB-RP096674h
Alternative Names	Huntingtin-interacting protein 2 ,HIP-2Ubiquitin carrier proteinUbiquitin-conjugating enzyme E2-25 kDa ,Ubiquitin-conjugating enzyme E2(25K) ,Ubiquitin-conjugating enzyme E2-25KUbiquitin-protein ligase, Huntingtin-interacting protein 2 ; HIP-2Ubiquitin carrier proteinUbiquitin-conjugating enzyme E2-25 kDa ; Ubiquitin-conjugating enzyme E2(25K) ; Ubiquitin-conjugating enzyme E2-25KUbiquitin-protein ligase
Tag	N-terminal 6xHis-tagged
Regulatory	RUO
Relevance	Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro, in the presence or in the absence of BRCA1-BARD1 E3 ubiquitin-protein ligase complex, catalyzes the synthesis of 'Lys-48'-linked polyubiquitin chains. Does not transfer ubiquitin directly to but elongates monoubiquitinated substrate protein. Mediates the selective degradation of short-lived and abnormal proteins, such as the endoplasmic reticulum-associated degradation (ERAD) of misfolded lumenal proteins. Ubiquitinates huntingtin. May mediate foam cell formation by the suppression of apoptosis of lipid-bearing macrophages through ubiquitination and subsequence degradation of p53/TP53. Proposed to be involved in ubiquitination and proteolytic processing of NF-kappa-B; in vitro supports ubiquitination of NFKB1. In case of infection by cytomegaloviruses may be involved in the US11-dependent degradation of MHC class I heavy chains following their export from the ER to the cytosol. In case of viral infections may be involved in the HPV E7 protein-dependent degradation of RB1
Source	E.coli
Notes	Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Expression Region	2-200aa
Mol Weight	26.3kDa
Nature	recombinant
Protein Description	Full Length of Mature Protein

Subcellular Location	Cytoplasm
Uniprot	P61086, P61086
Database Links	HGNC:4914 OMIM:602846 KEGG:hsa:3093 STRING:9606.ENSP00000261427 UniGene:Hs.50308
Function	Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro, in the presence or in the absence of BRCA1-BARD1 E3 ubiquitin-protein ligase complex, catalyzes the synthesis of 'Lys-48'-linked polyubiquitin chains. Does not transfer ubiquitin directly to but elongates monoubiquitinated substrate protein. Mediates the selective degradation of short-lived and abnormal proteins, such as the endoplasmic reticulum-associated degradation (ERAD) of misfolded lumenal proteins. Ubiquitinates huntingtin. May mediate foam cell formation by the suppression of apoptosis of lipid-bearing macrophages through ubiquitination and subsequence degradation of p53/TP53. Proposed to be involved in ubiquitination and proteolytic processing of NF-kappa-B; in vitro supports ubiquitination of NFKB1. In case of infection by cytomegaloviruses may be involved in the US11-dependent degradation of MHC class I heavy chains following their export from the ER to the cytosol. In case of viral infections may be involved in the HPV E7 protein-dependent degradation of RB1.
Pathway	Ubiquitin mediated proteolysis
Protein Families	Ubiquitin-conjugating enzyme family
Research Area	Neuroscience
Tissue Specificity	Expressed in all tissues tested, including spleen, thymus, prostate, testis, ovary, small intestine, colon, peripheral blood leukocytes, T-lymphocytes, monocytes, granulocytes and bone marrow mononuclear cells. Highly expressed in brain, with highest leve
Weight	26.4kDa

Stotage Note	Repeated freezing and thawing is not recommended. Store working aliquots at 4℃ for up to one week.
Buffer	Tris-based buffer，50% glycerol
Purity	Greater than 90% as determined by SDS-PAGE.
Storage	The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Storage Buffer	Tris-based buffer,50% glycerol

Immunogen Species	Homo Sapiens (Human)

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SKU	Supplier No.	Size	Your price	Quantity
BHP10501954	CSB-RP096674h	1mg	$1812		Add to Cart
BHP10501954	CSB-RP096674h	100ug	$419		Add to Cart
BHP10501954	CSB-RP096674h	20ug	$224		Add to Cart

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