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Home / Proteins & Peptide

Recombinant Human Tumor susceptibility gene 101 protein(TSG101),partial

SKU : BHP10505403

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CUSABIO TECHONOLOGY LLC

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Mfr.No.	CSB-EP860355HU1
Description	Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Binds to ubiquitinated cargo proteins and is required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies (MVBs). Mediates the association between the ESCRT-0 and ESCRT-I complex. Required for completion of cytokinesis; the function requires CEP55. May be involved in cell growth and differentiation. Acts as a negative growth regulator. Involved in the budding of many viruses through an interaction with viral proteins that contain a late-budding motif P-[ST]-A-P. This interaction is essential for viral particle budding of numerous retroviruses. Required for the exosomal release of SDCBP, CD63 and syndecan
Alternative Names	ESCRT-I complex subunit TSG101
Tag	N-terminal 10xHis-SUMO-tagged and C-terminal Myc-tagged
Regulatory	RUO
Relevance	Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Binds to ubiquitinated cargo proteins and is required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies (MVBs). Mediates the association between the ESCRT-0 and ESCRT-I complex. Required for completion of cytokinesis; the function requires CEP55. May be involved in cell growth and differentiation. Acts as a negative growth regulator. Involved in the budding of many viruses through an interaction with viral proteins that contain a late-budding motif P-[ST]-A-P. This interaction is essential for viral particle budding of numerous retroviruses. Required for the exosomal release of SDCBP, CD63 and syndecan
Source	E.coli
Notes	Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Protein Name	ESCRT-I complex subunit TSG101
Expression Region	1-145aa
Mol Weight	36.6 kDa
Nature	Recombinant
Protein Description	Partial

Subcellular Location	Cytoplasm, Early endosome membrane, Peripheral membrane protein, Cytoplasmic side, Late endosome membrane, Peripheral membrane protein, Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, Midbody, Midbody ring, Nucleus
Uniprot	Q99816, Q99816
Database Links	HGNC:15971 OMIM:601387 KEGG:hsa:7251 STRING:9606.ENSP00000251968 UniGene:Hs.523512
Function	Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Binds to ubiquitinated cargo proteins and is required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies (MVBs). Mediates the association between the ESCRT-0 and ESCRT-I complex. Required for completion of cytokinesis; the function requires CEP55. May be involved in cell growth and differentiation. Acts as a negative growth regulator. Involved in the budding of many viruses through an interaction with viral proteins that contain a late-budding motif P-[ST]-A-P. This interaction is essential for viral particle budding of numerous retroviruses. Required for the exosomal release of SDCBP, CD63 and syndecan
Pathway	Endocytosis; Secreted Extracellular Vesicles
Protein Families	Ubiquitin-conjugating enzyme family, UEV subfamily
Research Area	Others
Tissue Specificity	Heart, brain, placenta, lung, liver, skeletal, kidney and pancreas.
Weight	36.6 kDa

Stotage Note	Repeated freezing and thawing is not recommended. Store working aliquots at 4℃ for up to one week.
Buffer	Tris-based buffer，50% glycerol
Purity	Greater than 85% as determined by SDS-PAGE.
Storage	The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Storage Buffer	Tris-based buffer，50% glycerol

Immunogen Species	Homo Sapiens (Human)

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SKU	Supplier No.	Size	Your price	Quantity
BHP10505403	CSB-EP860355HU1	1mg	$2466		Add to Cart
BHP10505403	CSB-EP860355HU1	100ug	$578		Add to Cart
BHP10505403	CSB-EP860355HU1	20ug	$306		Add to Cart

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