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Home / Proteins & Peptide

Recombinant Human Tumor necrosis factor receptor superfamily member 6 protein(FAS) (Active)

SKU : BHP10500223

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CUSABIO TECHONOLOGY LLC

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Mfr.No.	CSB-AP002311HU
Alternative Names	Apo-1 antigen, FASLG receptor, CD antigen CD95, Apo-1 antigen ; FASLG receptor ; CD antigen CD95
Pubmed Id	1713127; 1375228; 7575433; 7533181; 8598453; 8648105; 17336828; 14702039; 15164054; 15489334; 7538908; 10542291; 10535980; 14759258; 15465831; 18691976; 18669648; 19159218; 21109225; 20068231; 21269460; 22171320; 24275569; 8967952; 19118384; 7540117; 8929
Regulatory	RUO
Source	E.coli
Endotoxin Level	Less than 1.0 EU/μg as determined by LAL method.
Bioactivity	Fully biologically active when compared to standard. The ED50 as determined by its ability to inhibit the cytotoxicity of Jurkat cells is between 10-15 ug/ml in the presence of 2 ng/ml of rHuFas Ligand.
Expression Region	17-173aa
Mol Weight	17.6 kDa
Nature	recombinant
Protein Description	Partial

Involvement In Disease	Autoimmune lymphoproliferative syndrome 1A (ALPS1A)
Subcellular Location	Isoform 1: Cell membrane, Single-pass type I membrane protein, SUBCELLULAR LOCATION: Isoform 2: Secreted, SUBCELLULAR LOCATION: Isoform 3: Secreted, SUBCELLULAR LOCATION: Isoform 4: Secreted, SUBCELLULAR LOCATION: Isoform 5: Secreted, SUBCELLULAR LOCATION: Isoform 6: Secreted
Uniprot	P25445, P25445
Database Links	HGNC:11920 OMIM:134637 KEGG:hsa:355 STRING:9606.ENSP00000347979 UniGene:Hs.244139
Function	Receptor for TNFSF6/FASLG. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. FAS-mediated apoptosis may have a role in the induction of peripheral tolerance, in the antigen-stimulated suicide of mature T-cells, or both. The secreted isoforms 2 to 6 block apoptosis (in vitro).
Pathway	MAPK signaling pathway; p53 signaling pathway; TNF signaling pathway; Apoptosis; Necroptosis; Natural killer cell mediated cytotoxicity
Research Area	Cancer
Tissue Specificity	Isoform 1 and isoform 6 are expressed at equal levels in resting peripheral blood mononuclear cells. After activation there is an increase in isoform 1 and decrease in the levels of isoform 6.
Weight	17.6 kDa

Buffer	0.2 µm filtered PBS, pH 7.4,lyophilized
Purity	>95% as determined by SDS-PAGE and HPLC.
Storage Buffer	0.2 μm filtered PBS, pH 7.4 ,lyophilized

Immunogen Species	Homo Sapiens (Human)

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SKU	Supplier No.	Size	Your price	Quantity
BHP10500223	CSB-AP002311HU	500ug	$3402		Add to Cart
BHP10500223	CSB-AP002311HU	100ug	$1516		Add to Cart
BHP10500223	CSB-AP002311HU	5ug	$142		Add to Cart

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