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Recombinant Human Tumor necrosis factor receptor superfamily member 1B protein(TNFRSF1B),partial (Active)

SKU : BHP10500228

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CUSABIO TECHONOLOGY LLC

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Mfr.No.	CSB-AP002371HU
Alternative Names	Tumor necrosis factor receptor 2, Tumor necrosis factor receptor type II, TNF-RII, TNFR-II, p75, Tumor necrosis factor receptor 2 ; Tumor necrosis factor receptor type II ; TNF-RII ; TNFR-II ; p75
Pubmed Id	2172983; 2160731; 8661109; 14688072; 16710414; 15489334; 2173696; 8015639; 2153136; 1966549; 2166946; 11197692; 1328224; 8069916; 12370298; 25456591; 10206649; 11762942; 12161545
Regulatory	RUO
Source	E.coli
Endotoxin Level	Less than 1.0 EU/μg as determined by LAL method.
Bioactivity	Fully biologically active when compared to standard. The ED50 as determined by its ability to inhibit the TNF-α mediated cytotoxicity in the L-929 cells is less than 0.2 μg/ml, corresponding to a specific activity of >5000 IU/mg in the presence of 0.25 ng/mL of rHuTNF-α.
Expression Region	23-206aa
Mol Weight	20.0 kDa
Nature	recombinant
Protein Description	Partial

Subcellular Location	Isoform 1: Cell membrane, Single-pass type I membrane protein, SUBCELLULAR LOCATION: Isoform 2: Secreted, SUBCELLULAR LOCATION: Tumor necrosis factor-binding protein 2: Secreted
Uniprot	P20333, P20333
Database Links	HGNC:11917 OMIM:191191 KEGG:hsa:7133 STRING:9606.ENSP00000365435 UniGene:Hs.256278
Function	Receptor with high affinity for TNFSF2/TNF-alpha and approximately 5-fold lower affinity for homotrimeric TNFSF1/lymphotoxin-alpha. The TRAF1/TRAF2 complex recruits the apoptotic suppressors BIRC2 and BIRC3 to TNFRSF1B/TNFR2. This receptor mediates most of the metabolic effects of TNF-alpha. Isoform 2 blocks TNF-alpha-induced apoptosis, which suggests that it regulates TNF-alpha function by antagonizing its biological activity.
Pathway	TNF signaling pathway; Adipocytokine signaling pathway
Research Area	Cancer
Weight	20.0 kDa

Buffer	0.2 µm filtered PBS, pH 7.4,lyophilized
Purity	>97% as determined by SDS-PAGE and HPLC.
Storage Buffer	0.2 μm filtered PBS, pH 7.4 ,lyophilized

Immunogen Species	Homo Sapiens (Human)

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SKU	Supplier No.	Size	Your price	Quantity
BHP10500228	CSB-AP002371HU	500ug	$2618		Add to Cart
BHP10500228	CSB-AP002371HU	100ug	$1166		Add to Cart
BHP10500228	CSB-AP002371HU	5ug	$142		Add to Cart

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