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Home / Proteins & Peptide

Recombinant Human Tumor necrosis factor ligand superfamily member 6(FASLG),partial

SKU : BHP10500530

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CUSABIO TECHONOLOGY LLC

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Mfr.No.	CSB-EP008434HU
Alternative Names	Apoptosis antigen ligand ,APTLCD95 ligand ,CD95-LFas antigen ligand ,Fas ligand ,FasL, CD178, Apoptosis antigen ligand ; APTLCD95 ligand ; CD95-LFas antigen ligand ; Fas ligand ; FasL ; CD178
Tag	N-terminal 6xHis-tagged
Regulatory	RUO
Relevance	Cytokine that binds to TNFRSF6/FAS, a receptor that transduces the apoptotic signal into cells. May be involved in cytotoxic T-cell mediated apoptosis and in T-cell development. TNFRSF6/FAS-mediated apoptosis may have a role in the induction of peripheral tolerance, in the antigen-stimulated suicide of mature T-cells, or both. Binding to the decoy receptor TNFRSF6B/DcR3 modulates its effects.
Source	E.coli
Notes	Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Expression Region	130-281aa
Mol Weight	21.3kDa
Nature	recombinant
Protein Description	Partial

Involvement In Disease	Autoimmune lymphoproliferative syndrome 1B (ALPS1B)
Subcellular Location	Cell membrane, Single-pass type II membrane protein, Cytoplasmic vesicle lumen, Lysosome lumen, Note=Is internalized into multivesicular bodies of secretory lysosomes after phosphorylation by FGR and monoubiquitination (PubMed:17164290), Colocalizes with the SPPL2A protease at the cell membrane (PubMed:17557115), SUBCELLULAR LOCATION: Tumor necrosis factor ligand superfamily member 6, soluble form: Secreted, Note=May be released into the extracellular fluid by cleavage from the cell surface, SUBCELLULAR LOCATION: FasL intracellular domain: Nucleus
Uniprot	P48023, P48023
Database Links	HGNC:11936 OMIM:134638 KEGG:hsa:356 STRING:9606.ENSP00000356694 UniGene:Hs.2007
Function	Cytokine that binds to TNFRSF6/FAS, a receptor that transduces the apoptotic signal into cells
Pathway	MAPK signaling pathway; PI3K-Akt signaling pathway; Apoptosis; Necroptosis; Ras signaling pathway; Natural killer cell mediated cytotoxicity; FoxO signaling pathway; Neurotrophin signaling pathway
Protein Families	Tumor necrosis factor family
Research Area	Apoptosis
Weight	21.4kDa

Stotage Note	Repeated freezing and thawing is not recommended. Store working aliquots at 4℃ for up to one week.
Buffer	Tris-based buffer，50% glycerol
Purity	Greater than 90% as determined by SDS-PAGE.
Storage	The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Storage Buffer	Tris-based buffer,50% glycerol

Immunogen Species	Homo Sapiens (Human)

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SKU	Supplier No.	Size	Your price	Quantity
BHP10500530	CSB-EP008434HU	1mg	$1812		Add to Cart
BHP10500530	CSB-EP008434HU	100ug	$419		Add to Cart
BHP10500530	CSB-EP008434HU	20ug	$224		Add to Cart

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