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Recombinant Human Trimethylguanosine synthase(TGS1) ,partial

SKU : BHP10501473

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CUSABIO TECHONOLOGY LLC

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Mfr.No.	CSB-EP847219HU
Alternative Names	CLL-associated antigen KW-2,Cap-specific guanine-N2 methyltransferaseHepatocellular carcinoma-associated antigen 137Nuclear receptor coactivator 6-interacting protein,PRIP-interacting protein with methyltransferase motif ,PIMT ,PIPMT, CLL-associated antigen KW-2 ; Cap-specific guanine-N2 methyltransferaseHepatocellular carcinoma-associated antigen 137Nuclear receptor coactivator 6-interacting protein ; PRIP-interacting protein with methyltransferase motif ; PIMT ; PIPMT
Tag	N-terminal 6xHis-SUMO-tagged
Regulatory	RUO
Relevance	Catalyzes the 2 serial methylation steps for the conversion of the 7-monomethylguanosine (m7G) caps of snRNAs and snoRNAs to a 2,2,7-trimethylguanosine (m(2,2,7)G) cap structure. The enzyme is specific for guanine, and N7 methylation must precede N2 methylation. Hypermethylation of the m7G cap of U snRNAs leads to their concentration in nuclear foci, their colocalization with coilin and the formation of canonical Cajal bodies (CBs). Plays a role in transcriptional regulation.
Source	E.coli
Notes	Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Expression Region	713-853aa
Mol Weight	31.6kDa
Nature	recombinant
Protein Description	Partial

Subcellular Location	Cytoplasm, Nucleus, Cajal body, Nucleus, nucleolus
Uniprot	Q96RS0, Q96RS0
Database Links	HGNC:17843 OMIM:606461 KEGG:hsa:96764 STRING:9606.ENSP00000260129 UniGene:Hs.335068
Function	Catalyzes the 2 serial methylation steps for the conversion of the 7-monomethylguanosine (m(7)G) caps of snRNAs and snoRNAs to a 2,2,7-trimethylguanosine (m(2,2,7)G) cap structure. The enzyme is specific for guanine, and N7 methylation must precede N2 methylation. Hypermethylation of the m7G cap of U snRNAs leads to their concentration in nuclear foci, their colocalization with coilin and the formation of canonical Cajal bodies (CBs). Plays a role in transcriptional regulation.
Protein Families	Methyltransferase superfamily, Trimethylguanosine synthase family
Research Area	Epigenetics and Nuclear Signaling
Tissue Specificity	Ubiquitously expressed. High expression in heart, skeletal muscle, kidney, liver and placenta.
Weight	31.64kDa

Stotage Note	Repeated freezing and thawing is not recommended. Store working aliquots at 4℃ for up to one week.
Buffer	Tris-based buffer，50% glycerol
Purity	Greater than 90% as determined by SDS-PAGE.
Storage	The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Storage Buffer	Tris-based buffer,50% glycerol

Immunogen Species	Homo Sapiens (Human)

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SKU	Supplier No.	Size	Your price	Quantity
BHP10501473	CSB-EP847219HU	1mg	$1812		Add to Cart
BHP10501473	CSB-EP847219HU	100ug	$419		Add to Cart
BHP10501473	CSB-EP847219HU	20ug	$224		Add to Cart

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