Recombinant Human Transcription factor PU.1(SPI1)

Mfr.No.	CSB-EP022567HU
Description	Binds to the PU-box, a purine-rich DNA sequence (5'-GAGGAA-3') that can act as a lymphoid-specific enhancer. This protein is a transcriptional activator that may be specifically involved in the differentiation or activation of macrophages or B-cells. Also binds RNA and may modulate pre-mRNA splicing
Alternative Names	31KDA-transforming protein
Tag	N-terminal 6xHis-tagged
Regulatory	RUO
Relevance	Binds to the PU-box, a purine-rich DNA sequence (5'-GAGGAA-3') that can act as a lymphoid-specific enhancer. This protein is a transcriptional activator that may be specifically involved in the differentiation or activation of macrophages or B-cells. Also binds RNA and may modulate pre-mRNA splicing
Source	E.coli
Notes	Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Protein Name	31 kDa-transforming protein
Expression Region	1-270aa
Mol Weight	35.1kDa
Nature	Recombinant
Protein Description	Full Length

Subcellular Location	Nucleus
Uniprot	P17947, P17947
Database Links	HGNC:11241 OMIM:165170 KEGG:hsa:6688 STRING:9606.ENSP00000227163 UniGene:Hs.502511
Function	Binds to the PU-box, a purine-rich DNA sequence (5'-GAGGAA-3') that can act as a lymphoid-specific enhancer. This protein is a transcriptional activator that may be specifically involved in the differentiation or activation of macrophages or B-cells. Also binds RNA and may modulate pre-mRNA splicing (By similarity).
Pathway	Osteoclast differentiation
Protein Families	ETS family
Research Area	Immunology
Weight	35.1 kDa

Stotage Note	Repeated freezing and thawing is not recommended. Store working aliquots at 4℃ for up to one week.
Buffer	Tris-based buffer，50% glycerol
Purity	Greater than 85% as determined by SDS-PAGE.
Storage	The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Storage Buffer	Tris-based buffer,50% glycerol