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Home / Proteins & Peptide

Recombinant Human Transcription factor 7-like 2(TCF7L2),partial

SKU : BHP10503318

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CUSABIO TECHONOLOGY LLC

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Mfr.No.	CSB-EP889079HU
Alternative Names	HMG box transcription factor 4, T-cell-specific transcription factor 4, T-cell factor 4, TCF-4, hTCF-4, HMG box transcription factor 4 ; T-cell-specific transcription factor 4 ; T-cell factor 4 ; TCF-4 ; hTCF-4
Tag	N-terminal 6xHis-tagged
Regulatory	RUO
Relevance	Participates in the Wnt signaling pathway and modulates MYC expression by binding to its promoter in a sequence-specific manner. Acts as repressor in the absence of CTNNB1, and as activator in its presence. Activates transcription from promoters with several copies of the Tcf motif 5'-CCTTTGATC-3' in the presence of CTNNB1. TLE1, TLE2, TLE3 and TLE4 repress transactivation mediated by TCF7L2/TCF4 and CTNNB1. Expression of dominant-negative mutants results in cell-cycle arrest in G1. Necessary for the maintenance of the epithelial stem-cell compartment of the small intestine.
Source	E.coli
Abbreviation	TCF7L2
Notes	Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Protein Name	Recommended name: Transcription factor 7-like 2Alternative name(s): HMG box transcription factor 4 T-cell-specific transcription factor 4 Short name= T-cell factor 4 Short name= TCF-4 Short name= hTCF-4
Expression Region	1-456aa
Mol Weight	54.9kDa
Nature	recombinant
Protein Description	Partial

Involvement In Disease	Diabetes mellitus, non-insulin-dependent (NIDDM)
Subcellular Location	Nucleus, PML body
Uniprot	Q9NQB0, Q9NQB0
Database Links	HGNC:11641 OMIM:125853 KEGG:hsa:6934 STRING:9606.ENSP00000444972 UniGene:Hs.593995
Function	Participates in the Wnt signaling pathway and modulates MYC expression by binding to its promoter in a sequence-specific manner. Acts as repressor in the absence of CTNNB1, and as activator in its presence. Activates transcription from promoters with several copies of the Tcf motif 5'-CCTTTGATC-3' in the presence of CTNNB1. TLE1, TLE2, TLE3 and TLE4 repress transactivation mediated by TCF7L2/TCF4 and CTNNB1. Expression of dominant-negative mutants results in cell-cycle arrest in G1. Necessary for the maintenance of the epithelial stem-cell compartment of the small intestine.
Pathway	Hippo signaling pathway; Melanogenesis; Wnt signaling pathway; Adherens junction
Protein Families	TCF/LEF family
Research Area	Epigenetics and Nuclear Signaling
Tissue Specificity	Detected in epithelium from small intestine, with the highest expression at the top of the crypts and a gradient of expression from crypt to villus. Detected in colon epithelium and colon cancer, and in epithelium from mammary gland and carcinomas derived
Weight	54.26kDa

Stotage Note	Repeated freezing and thawing is not recommended. Store working aliquots at 4℃ for up to one week.
Buffer	Tris-based buffer，50% glycerol
Purity	Greater than 90% as determined by SDS-PAGE.
Storage	The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Storage Buffer	Tris-based buffer,50% glycerol

Immunogen Species	Homo Sapiens (Human)

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SKU	Supplier No.	Size	Your price	Quantity
BHP10503318	CSB-EP889079HU	1mg	$2466		Add to Cart
BHP10503318	CSB-EP889079HU	100ug	$578		Add to Cart
BHP10503318	CSB-EP889079HU	20ug	$306		Add to Cart

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