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Home / Proteins & Peptide

Recombinant Human tPA/PLAT Protein (aa 37-310, Fc Tag)

SKU : BHP10303065

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Elabscience Biotechnology Co.,Ltd

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Mfr.No.	PKSH031825
Description	A DNA sequence encoding the alpha chain (Tyr 37-Arg 310) of mature human tPA (NP_000921.1) was expressed with the fused Fc region of human IgG1 at the N-terminus.
Alternative Names	T-PA; TPA; t-plasminogen activator; Tissue plasminogen activator;
Reconstitution	Please refer to the printed manual for detailed information.
Background	Tissue plasminogen activator (abbreviated tPA or PLAT), is traditionally viewed as a simple serine protease whose main function is to convert plasminogen into biologically active plasmin. As a protease, tPA plays a crucial role in regulating blood fibrinolysis, in maintaining the homeostasis of extracellular matrix and in modulating the post-translational activation of growth factors. tPA is synthesized and secreted as a single chain polypeptide precursor which is cleaved in turn by plasmin. Proteolytic cleavage at the C-terminal side of Arg275 generates the enzyme composed of two subunits, designated as α and β chains which are held together by a single disulfide bond. Unlike the other members of the chymotrypsin family, tPA has one particular distinction in that the catalytic efficiency of the single-chain enzyme is only slightly lower than that of the proteolytically cleaved form and is therefore not a true zymogen. tPA is found not only in the blood, where its primary function is as a thrombolytic enzyme, but also in the central nervous system (CNS). It participats in a number of physiological and pathological events in the CNS, as well as the role of neuroserpin as the natural regulator of tPA's activity in these processes. Increased or decreased activity of tPA leads to hyperfibrinolysis or hypofibrinolysis, respectively. In addition, as a cytokine, tPA plays a pivotal role in the pathogenesis of renal interstitial fibrosis through diverse mechanisms. Thus, as a fibrogenic cytokine, it promotes the progression of kidney diseases.
Reactivity	Human
Tag	N-Fc
Formulation	Lyophilized from sterile 50mM NaAc, 150mM NaCl, 5mM CaCl2, 10% glycerol, PH 5.5
Host	HEK293 Cells
Accession Number	NP_000921.1
Endotoxin Level	< 1.0 EU per ug as determined by the LAL method.
Mol Weight	57.5 kDa
Mw(kda)	57.5 kDa

Sequence Info	Tyr 37-Arg 310

Shipping	This product is provided as lyophilized powder which is shipped with ice packs.
Stotage Note	Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
Purity	> 95 % as determined by reducing SDS-PAGE.

Product Manual	Data Sheet

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SKU	Supplier No.	Size	Your price	Quantity
BHP10303065	PKSH031825	20ug	$612		Add to Cart

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