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Home / Proteins & Peptide

Recombinant Human Tissue-type plasminogen activator(PLAT),partial

SKU : BHP10500817

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CUSABIO TECHONOLOGY LLC

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Mfr.No.	CSB-EP018120HU(A5)
Alternative Names	INN: AlteplaseINN: Reteplase
Tag	N-terminal 6xHis-SUMO-tagged
Regulatory	RUO
Relevance	Converts the abundant, but inactive, zymogen plasminogen to plasmin by hydrolyzing a single Arg-Val bond in plasminogen. By controlling plasmin-mediated proteolysis, it plays an important role in tissue rodeling and degradation, in cell migration and many other physiopathological events. Plays a direct role in facilitating neuronal migration.
Source	E.coli
Notes	Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Expression Region	311-556aa
Mol Weight	43.4kDa
Nature	recombinant
Protein Description	Partial

Involvement In Disease	Increased activity of TPA results in increased fibrinolysis of fibrin blood clots that is associated with excessive bleeding. Defective release of TPA results in hypofibrinolysis that can lead to thrombosis or embolism.
Subcellular Location	Secreted, extracellular space
Uniprot	P00750, P00750
Database Links	HGNC:9051 OMIM:173370 KEGG:hsa:5327 STRING:9606.ENSP00000220809 UniGene:Hs.491582
Function	Converts the abundant, but inactive, zymogen plasminogen to plasmin by hydrolyzing a single Arg-Val bond in plasminogen. By controlling plasmin-mediated proteolysis, it plays an important role in tissue remodeling and degradation, in cell migration and many other physiopathological events. Plays a direct role in facilitating neuronal migration.
Pathway	Complement and coagulation cascades; Apelin signaling pathway
Protein Families	Peptidase S1 family
Research Area	Cancer
Tissue Specificity	Synthesized in numerous tissues (including tumors) and secreted into most extracellular body fluids, such as plasma, uterine fluid, saliva, gingival crevicular fluid, tears, seminal fluid, and milk.
Weight	43kDa

Stotage Note	Repeated freezing and thawing is not recommended. Store working aliquots at 4℃ for up to one week.
Buffer	Tris-based buffer，50% glycerol
Purity	Greater than 90% as determined by SDS-PAGE.
Storage	The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Storage Buffer	Tris-based buffer,50% glycerol

Immunogen Species	Homo Sapiens (Human)

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SKU	Supplier No.	Size	Your price	Quantity
BHP10500817	CSB-EP018120HU(A5)	1mg	$1812		Add to Cart
BHP10500817	CSB-EP018120HU(A5)	100ug	$419		Add to Cart
BHP10500817	CSB-EP018120HU(A5)	20ug	$224		Add to Cart

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