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Home / Proteins & Peptide

Recombinant Human TIR domain-containing adapter molecule 2(TICAM2)

SKU : BHP10503678

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CUSABIO TECHONOLOGY LLC

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Mfr.No.	CSB-EP774830HU
Alternative Names	Putative NF-kappa-B-activating protein 502, TRIF-related adapter molecule, Toll-like receptor adaptor protein 3, Toll/interleukin-1 receptor domain-containing protein, Putative NF-kappa-B-activating protein 502 ; TRIF-related adapter molecule ; Toll-like receptor adaptor protein 3 ; Toll/interleukin-1 receptor domain-containing protein
Antigen	TICAM2
Tag	N-terminal GST-tagged
Regulatory	RUO
Relevance	Functions as sorting adapter in LPS-TLR4 signaling to regulate the MYD88-independent pathway during the innate immune response to LPS. Physically bridges TLR4 and TICAM1 and functionally transmits LPS-TRL4 signal to TICAM1; signaling is proposed to occur in early endosomes after endocytosis of TLR4. May also be involved in IL1-triggered NF-kappa-B activation, functioning upstream of IRAK1, IRAK2, TRAF6, and IKBKB; however, reports are controversial. Involved in IL-18 signaling and is proposed to function as a sorting adaptor for MYD88 in IL-18 signaling during adaptive immune response. Isoform 2: Proposed to inhibit LPS-TLR4 signaling at the late endosome by interaction with isoform 1 thereby disrupting the association of isoform 1 with TICAM1. May be involved in TLR4 degradation in late endosomes.
Source	E.coli
Abbreviation	TICAM2
Notes	Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Protein Name	Recommended name: TIR domain-containing adapter molecule 2; Short name= TICAM-2; Alternative name(s): Putative NF-kappa-B-activating protein 502; TRIF-related adapter molecule; Toll-like receptor adaptor protein 3; Toll/interleukin-1
Expression Region	1-235aa
Mol Weight	53.8kDa
Nature	recombinant
Protein Description	Full Length

Subcellular Location	Isoform 1: Cytoplasm, Golgi apparatus, Cell membrane, Endoplasmic reticulum, Early endosome membrane, Late endosome membrane, Note=Localized to the plasma membrane as a result of myristoylation, Phosphorylation on Ser-16 leads to its depletion from the membrane, Upon LPS stimulation colcoalizes with isoform 2 in late endosomes, SUBCELLULAR LOCATION: Isoform 2: Endoplasmic reticulum, Early endosome membrane, Late endosome membrane
Uniprot	Q86XR7, Q86XR7
Database Links	HGNC:21354 OMIM:608321 KEGG:hsa:100302736 STRING:9606.ENSP00000386341 UniGene:Hs.718838
Function	Functions as sorting adapter in LPS-TLR4 signaling to regulate the MYD88-independent pathway during the innate immune response to LPS. Physically bridges TLR4 and TICAM1 and functionally transmits LPS-TRL4 signal to TICAM1; signaling is proposed to occur in early endosomes after endocytosis of TLR4. May also be involved in IL1-triggered NF-kappa-B activation, functioning upstream of IRAK1, IRAK2, TRAF6, and IKBKB; however, reports are controversial. Involved in IL-18 signaling and is proposed to function as a sorting adaptor for MYD88 in IL-18 signaling during adaptive immune response.; FUNCTION
Research Area	Immunology
Tissue Specificity	Expressed in spleen, prostate, testis, uterus, small intestine, colon, peripheral blood leukocytes, heart, placenta, lung, liver, skeletal muscle, and pancreas Isoform 2 is ubiquitously expressed (at lower levels than isoform 1).
Weight	53.485kD

Stotage Note	Repeated freezing and thawing is not recommended. Store working aliquots at 4℃ for up to one week.
Buffer	Tris-based buffer，50% glycerol
Purity	Greater than 90% as determined by SDS-PAGE.
Storage	The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Storage Buffer	Tris-based buffer,50% glycerol

Immunogen Species	Homo Sapiens (Human)

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SKU	Supplier No.	Size	Your price	Quantity
BHP10503678	CSB-EP774830HU	1mg	$1812		Add to Cart
BHP10503678	CSB-EP774830HU	100ug	$419		Add to Cart
BHP10503678	CSB-EP774830HU	20ug	$224		Add to Cart

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