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Home / Proteins & Peptide

Recombinant Human TIR domain-containing adapter molecule 1(TICAM1)

SKU : BHP10505972

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CUSABIO TECHONOLOGY LLC

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Mfr.No.	CSB-CF811598HU
Description	Involved in innate immunity against invading pathogens. Adapter used by TLR3 and TLR4 (through TICAM2) to mediate NF-kappa-B and interferon-regulatory factor (IRF) activation, and to induce apoptosis. Ligand binding to these receptors results in TRIF recruitment through its TIR domain. Distinct protein-interaction motifs allow recruitment of the effector proteins TBK1, TRAF6 and RIPK1, which in turn, lead to the activation of transcription factors IRF3 and IRF7, NF-kappa-B and FADD respectively.
Alternative Names	Proline-rich, vinculin and TIR domain-containing protein B Putative NF-kappa-B-activating protein 502H Toll-interleukin-1 receptor domain-containing adapter protein inducing interferon beta
Tag	N-terminal 10xHis-tagged
Regulatory	RUO
Relevance	Involved in innate immunity against invading pathogens. Adapter used by TLR3 and TLR4 (through TICAM2) to mediate NF-kappa-B and interferon-regulatory factor (IRF) activation, and to induce apoptosis. Ligand binding to these receptors results in TRIF recruitment through its TIR domain. Distinct protein-interaction motifs allow recruitment of the effector proteins TBK1, TRAF6 and RIPK1, which in turn, lead to the activation of transcription factors IRF3 and IRF7, NF-kappa-B and FADD respectively.
Source	in vitro E.coli expression system
Notes	Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Protein Name	Proline-rich, vinculin and TIR domain-containing protein B; Putative NF-kappa-B-activating protein 502H; Toll-interleukin-1 receptor domain-containing adapter protein inducing interferon beta
Expression Region	1-712aa
Mol Weight	79.9kDa
Nature	Recombinant
Protein Description	Full Length

Involvement In Disease	Herpes simplex encephalitis 4 (HSE4)
Subcellular Location	Cytoplasmic vesicle, autophagosome
Uniprot	Q8IUC6, Q8IUC6
Database Links	HGNC:18348 OMIM:607601 KEGG:hsa:148022 STRING:9606.ENSP00000248244 UniGene:Hs.29344
Function	Involved in innate immunity against invading pathogens. Adapter used by TLR3 and TLR4 (through TICAM2) to mediate NF-kappa-B and interferon-regulatory factor (IRF) activation, and to induce apoptosis. Ligand binding to these receptors results in TRIF recruitment through its TIR domain. Distinct protein-interaction motifs allow recruitment of the effector proteins TBK1, TRAF6 and RIPK1, which in turn, lead to the activation of transcription factors IRF3 and IRF7, NF-kappa-B and FADD respectively.
Pathway	NF-kappa B signaling pathway; Necroptosis; NOD-like receptor signaling pathway; Toll-like receptor signaling pathway
Research Area	Immunology
Tissue Specificity	Ubiquitously expressed but with higher levels in liver.
Weight	79.9 kDa

Stotage Note	Repeated freezing and thawing is not recommended. Store working aliquots at 4℃ for up to one week.
Buffer	Tris-based buffer，50% glycerol
Purity	Greater than 90% as determined by SDS-PAGE.
Storage	The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Storage Buffer	Tris-based buffer,50% glycerol

Immunogen Species	Homo Sapiens (Human)

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SKU	Supplier No.	Size	Your price	Quantity
BHP10505972	CSB-CF811598HU	100ug	$1711		Add to Cart
BHP10505972	CSB-CF811598HU	20ug	$878		Add to Cart

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