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Home / Proteins & Peptide

Recombinant Human TIMP2/TIMP-2 Protein (Fc Tag)

SKU : BHP10300141

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Elabscience Biotechnology Co.,Ltd

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Mfr.No.	PKSH030472
Description	A DNA sequence encoding the mature form of human TIMP2 (NP_003246.1) (Cys 27-Pro 220) was expressed with the fused Fc region of human IgG1 at the N-terminus.
Alternative Names	CSC-21K ; TIMP2
Background	Tissue inhibitors of metalloproteinases (TIMP) family are natural inhibitors of the matrix metalloproteinases (MMPs), the zinc enzymes involved in extracellular matrix maintenance and remodeling. The TIMP family encompasses four members (TIMP1-4), and they inhibit most MMPs by forming non-covalent binary complex. TIMP2 is a 22 kDa non N-glycosylated protein expressed by a variety of cell types, and plays a unique role among TIMP family members owing to its functions to regulate cellular responses to growth factors. Findings establish an unexpected, MMP-independent mechanism for TIMP2 inhibition of endothelial cell proliferation in vitro and reveal an important component of the antiangiogenic effect of TIMP2 in vivo. TIMP-2 thus is critical to the maintenance of tissue homeostasis and is involved in the regulation of tumor microenvironment.
Tag	Fc tag
Regulatory	RUO
Host	Human Cells
Endotoxin Level	< 1.0 EU per μg of the protein as determined by the LAL method
Nature	Recombinant

Shipping	In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature.Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise.
Buffer	Lyophilized from sterile 100mM Glycine, 10mM NaCl, 50mM Tris, pH 7.5
Description	Please refer to the printed manual for detailed information.
Purity	> 95 % as determined by SDS-PAGE
Expiry Date	Samples are stable for up to twelve months from date of receipt at -70℃

Immunogen Species	Homo Sapiens (Human)

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SKU	Supplier No.	Size	Your price	Quantity
BHP10300141	PKSH030472	20ug	$486		Add to Cart

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