The primary function of the T beta-4 member of the Thymosin-beta family is to maintain the organization of the cell’s cytoskeletal structure. Produced by myoblasts and fibroblasts, TMSB4X acts as a modulator for the production and digestion of actin and to inhibit filamentous actin polymerization. TMSB4X has also been found to induce phenotypic changes in T cell lines during early host defence mechanisms and inhibit the progression of hematopoietic pluripotent stem cells into the s-phase.
Alternative Names
T beta-4 ; Hematopoietic system regulatory peptide ; Seraspenide ; TMSB4X ; TB4X ; TMSB4
Appearance
Lyophilized Powder
Reconstitution
Reconstitute at 100 μg/mL in sterile PBS
Formulation
Lyophilized from a 0.2 μm filtered solution in PBS
Molecular Weight
5.2 kDa
Quantity
1.0 mg
Source
E. coli
Usage
For research use only. Not for diagnostic or therapeutic use.
Accession Number
P62328
Endotoxin Level
< 1.0 EU/μg of recombinant protein as determined by the LAL method.
Bioactivity
The ED(50) was determined by the dose-dependent proliferation of immortalized mouse brain endothelial cells and was found to be <0.5ng/mL.,
Gel Image
Gene Id
7114
Gene Name
TMSB4X
Purity
>95% as determined by SDS-PAGE
Storage
The lyophilized protein is stable for at least one year from date of receipt at -70°C. Upon reconstitution, this cytokine can be stored in working aliquots at 2° - 8°C for one month, or at -20°C for six months, with a carrier protein without detectable loss of activity.Avoid repeated freeze/thaw cycles.