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Home / Proteins & Peptide

Recombinant Human Thymidine kinase 2, mitochondrial(TK2)

SKU : BHP10505136

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CUSABIO TECHONOLOGY LLC

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Mfr.No.	CSB-EP023578HU
Alternative Names	Mt-TK
Antigen	TK2
Tag	N-terminal 10xHis-tagged and C-terminal Myc-tagged
Description	Phosphorylates thymidine, deoxycytidine, and deoxyuridine in the mitochondrial matrix. In non-replicating cells, where cytosolic dNTP synthesis is down-regulated, mtDNA synthesis depends solely on TK2 and DGUOK. Widely used as target of antiviral and chemotherapeutic agents.
Regulatory	RUO
Relevance	Phosphorylates thymidine, deoxycytidine, and deoxyuridine in the mitochondrial matrix. In non-replicating cells, where cytosolic dNTP synthesis is down-regulated, mtDNA synthesis depends solely on TK2 and DGUOK. Widely used as target of antiviral and chemotherapeutic agents.
Source	E.coli
Notes	Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Protein Name	Mt-TK
Expression Region	34-265aa
Mol Weight	32.5 kDa
Nature	Recombinant
Protein Description	Full Length of Mature Protein

Involvement In Disease	Mitochondrial DNA depletion syndrome 2 (MTDPS2); Progressive external ophthalmoplegia with mitochondrial DNA deletions, autosomal recessive 3 (PEOB3)
Subcellular Location	Mitochondrion
Uniprot	O00142, O00142
Database Links	HGNC:11831 OMIM:188250 KEGG:hsa:7084 STRING:9606.ENSP00000414334 UniGene:Hs.512619
Function	Phosphorylates thymidine, deoxycytidine, and deoxyuridine in the mitochondrial matrix. In non-replicating cells, where cytosolic dNTP synthesis is down-regulated, mtDNA synthesis depends solely on TK2 and DGUOK. Widely used as target of antiviral and chemotherapeutic agents.
Protein Families	DCK/DGK family
Research Area	Epigenetics and Nuclear Signaling
Tissue Specificity	Predominantly expressed in liver, pancreas, muscle, and brain.
Weight	32.5 kDa

Stotage Note	Repeated freezing and thawing is not recommended. Store working aliquots at 4℃ for up to one week.
Buffer	Tris-based buffer，50% glycerol
Purity	Greater than 85% as determined by SDS-PAGE.
Storage	The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Storage Buffer	Tris-based buffer,50% glycerol

Immunogen Species	Homo Sapiens (Human)

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SKU	Supplier No.	Size	Your price	Quantity
BHP10505136	CSB-EP023578HU	1mg	$1812		Add to Cart
BHP10505136	CSB-EP023578HU	100ug	$419		Add to Cart
BHP10505136	CSB-EP023578HU	20ug	$224		Add to Cart

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