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Home / Proteins & Peptide

Recombinant Human Thioredoxin-interacting protein(TXNIP)

SKU : BHP10503938

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CUSABIO TECHONOLOGY LLC

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Mfr.No.	CSB-CF880966HU
Alternative Names	Thioredoxin-binding protein 2 ; Vitamin D3 up-regulated protein 1
Tag	N-terminal 6xHis-SUMO-tagged
Regulatory	RUO
Relevance	May act as an oxidative stress mediator by inhibiting thioredoxin activity or by limiting its bioavailability. Interacts with COPS5 and restores COPS5-induced suppression of CDKN1B stability, blocking the COPS5-mediated translocation of CDKN1B from the nucleus to the cytoplasm. Functions as a transcriptional repressor, possibly by acting as a bridge molecule between transcription factors and corepressor complexes, and over-expression will induce G0/G1 cell cycle arrest. Required for the maturation of natural killer cells. Acts as a suppressor of tumor cell growth. Inhibits the proteasomal degradation of DDIT4, and thereby contributes to the inhibition of the mammalian target of rapamycin complex 1 (mTORC1).
Source	in vitro E.coli expression system
Notes	Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Protein Name	Thioredoxin-binding protein 2; Vitamin D3 up-regulated protein 1
Expression Region	1-391aa
Mol Weight	59.7kDa
Nature	recombinant
Protein Description	Full Length

Subcellular Location	Cytoplasm
Uniprot	Q9H3M7, Q9H3M7
Database Links	HGNC:16952 OMIM:606599 KEGG:hsa:10628 STRING:9606.ENSP00000358323 UniGene:Hs.533977
Function	May act as an oxidative stress mediator by inhibiting thioredoxin activity or by limiting its bioavailability. Interacts with COPS5 and restores COPS5-induced suppression of CDKN1B stability, blocking the COPS5-mediated translocation of CDKN1B from the nucleus to the cytoplasm. Functions as a transcriptional repressor, possibly by acting as a bridge molecule between transcription factors and corepressor complexes, and over-expression will induce G0/G1 cell cycle arrest. Required for the maturation of natural killer cells. Acts as a suppressor of tumor cell growth. Inhibits the proteasomal degradation of DDIT4, and thereby contributes to the inhibition of the mammalian target of rapamycin complex 1 (mTORC1).
Pathway	Inflammasome Signaling; NOD-like receptor signaling pathway
Protein Families	Arrestin family
Research Area	Others
Weight	59.4kDa

Stotage Note	Repeated freezing and thawing is not recommended. Store working aliquots at 4℃ for up to one week.
Buffer	Tris-based buffer，50% glycerol
Purity	Greater than 90% as determined by SDS-PAGE.
Storage	The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Storage Buffer	Tris-based buffer,50% glycerol

Immunogen Species	Homo Sapiens (Human)

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SKU	Supplier No.	Size	Your price	Quantity
BHP10503938	CSB-CF880966HU	100ug	$1420		Add to Cart
BHP10503938	CSB-CF880966HU	20ug	$878		Add to Cart

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