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Home / Proteins & Peptide

Recombinant Human TGF Beta-3 (TGFB3)

SKU : BHP10900815

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Applied Biological Materials (abm) Inc.

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Mfr.No.	Z102515
Description	Transforming Growth Factor Beta-3 is a disulfide-linked homodimeric, non-glycosylated, protein that is one of the isoforms of the highly pleiotropic cytokines that are secreted by all cell types. TGF Beta-1, TGF Beta-2, and TGF Beta-3 use the same receptor and act as cellular switches that regulate cell growth, proliferation, differentiation, motility, extracellular matrix synthesis, and immune function regulation. Defects of this gene can cause arrhythmogenic right ventricular dysplasia 1 and rienhoff syndrome. TGFB3 first interacts with the accessory receptor betaglycan (TGF Beta-R3) and a type II serine/threonine kinase receptor (TGF Beta-R2). The receptor then activates a type I serine/threonine kinase receptor such as ALK-1 or TGF Beta-R1 (ALK-5) through phosphorylation, and the activated type I receptor activates Smad proteins to regulate transcription.
Alternative Names	Transforming growth factor beta-3
Quantity	10 µg
Regulatory	RUO
Source	E. coli
Host	Human
Endotoxin Level	<1.0 EU/μg of recombinant protein as determined by the LAL method
Biological Activity Comment	The ED50 is 0.01-0.04 ng/mL as determined by its ability to inhibit IL-4 dependent proliferation of HT-2 mouse cells

Weight	13.0 kDa

Format	Liquid The filter sterilized clear protein solution contains 20% Ethanol and 0.12% Acetic acid.
Purity	>95% as determined by SDS-PAGE
Storage	This cytokine can be stored in working aliquots at 2° - 8°C for two weeks. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).

Immunogen Species	Homo Sapiens (Human)

MSDS	Growth Factors, Cytokines & Kinases MSDS
Other	Growth Factor and Cytokine Brochure

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SKU	Supplier No.	Size	Your price	Quantity
BHP10900815	Z102515	10µg	$411.11		Add to Cart

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