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Home / Proteins & Peptide

Recombinant Human TGF Beta-2 (TGFB2)

SKU : BHP10901053

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Applied Biological Materials (abm) Inc.

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Mfr.No.	Z103057
Description	TGF beta 2 belongs to the transforming growth factor beta (TGFB) family of cytokines, which are multifunctional peptides that regulate proliferation, differentiation, adhesion, migration, and other functions in many cell types, transducing signals through combinations of accessory receptor betaglycan (also known as TGF-beta RIII) and type II ser/thr kinase receptors TGF-beta RII and TGF-beta RI or alternatively, ALK-1. Their downstream effectors the SMAD proteins regulates transcription upon phosphorylation and activation. Disruption of the TGFB/SMAD pathway has been implicated in a variety of human cancers. TGF beta 2 is secreted and has suppressive effects of interleukin-2 dependent T-cell growth. Recombinant TGF beta 2 is expressed from human 293 cells as a mature disulfide-linked homodimer with a molecular mass of 25 kDa.
Alternative Names	Glioblastoma-derived T-cell suppressor factor ; G-TSF ; BSC-1 cell growth inhibitor ; Polyergin ; Cetermin ; Transforming growth factor beta 2 ; LDS4
Quantity	100 µg
Regulatory	RUO
Source	HEK293
Host	Human
Endotoxin Level	<1 EU/µg of recombinant protein as determined by the LAL method
Biological Activity Comment	The EC(50) as determined by the dose-dependent inhibition of IL-4 induced proliferation of mouse HT-2 cells (BALB/c spleen activated by sheep erythrocytes in the presence of IL-2) was found to be ≤ 0.5 ng/mL.

Weight	25 kDa, homodimer, nonglycosylated

Description	A quick spin of the vial followed by reconstitution in sterile 20% ethanol + 50 mM NaOAc + 75 mM HOAc.
Format	Lyophilized Powder 50 mM NaOAc pH 4.5
Purity	>95% as determined by SDS-PAGE
Storage	The lyophilized protein is stable for at least one year from date of receipt at -70°C. Upon reconstitution, this cytokine can be stored in working aliquots at 2° - 8°C for one month, or at -20°C for six months. Avoid repeated freeze/thaw cycles.

Immunogen Species	Homo Sapiens (Human)

MSDS	Growth Factors, Cytokines & Kinases MSDS
Other	Growth Factor and Cytokine Brochure

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SKU	Supplier No.	Size	Your price	Quantity
BHP10901053	Z103057	100µg	$3090.50		Add to Cart

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