Found in the gastrointestinal tract, the three Trefoil proteins, TFF1, 2, and 3 have been shown to play an important role in intestinal mucosal defence and repair. Specifically, TFF1 is essential for normal differentiation of the antral and pyloric gastric mucosa and functions as a gastric-specific tumor suppressor gene.
Alternative Names
Polypeptide P1.A ; Protein pS2 ; TFF1 ; Breast cancer estrogen-inducible protein ; BCEI ; PNR-2
Quantity
1.0 mg
Regulatory
RUO
Source
E. coli
Host
Human
Endotoxin Level
< 1.0 EU/μg of recombinant protein as determined by the LAL method.
Biological Activity Comment
The ED(50) was determined by the dose-dependent proliferation of MCF7 cells and was found to be <0.5ng/mL.
Weight
6.9 kDa
Description
Reconstitute at 100 μg/mL in sterile PBS
Format
Lyophilized PowderLyophilized from a 0.2 μm filtered solution in PBS
Purity
>95% as determined by SDS-PAGE
Storage
The lyophilized protein is stable for at least one year from date of receipt at -70°C. Upon reconstitution, this cytokine can be stored in working aliquots at 2° - 8°C for one month, or at -20°C for six months, with a carrier protein without detectable loss of activity.