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Home / Proteins & Peptide

Recombinant Human TAK1-TAB1 (N-GST tag)

SKU : BHP10900773

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Applied Biological Materials (abm) Inc.

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Mfr.No.	Z500378
Description	TAK1 is a serine/threonine protein kinase that mediates signaling by TGFß and morphogenetic protein (BMP) . In response to IL-1, TAK1 forms a kinase complex with TAB1 and this complex is required for the activation of nuclear factor kappa B (Nf?B). TAK1 can also activate MAPK8/JNK and MAP2K4/MKK4 and thus play a role in the cell response to environmental stress. Tak1 is essential for thymocyte development and activation and deletion of TAK1 prevents maturation of single-positive thymocytes displaying CD4 or CD8 . Thymocytes lacking TAK1 fail to activate Nf?B and JNK and are prone to apoptosis upon stimulation.
Alternative Names	TGF1a ; TAB1: MAP3K7IP1 ; 3'-Tab1 ; MGC57664 ; TAK1: MAP3K7
Tag	N-GST tag
Quantity	10 µg
Regulatory	RUO
Source	Insect cells
Host	Human
Biological Activity Comment	The specific activity of TAK1-TAB1 was determined to be 10 nmol /min/mg as per activity assay protocol.

Weight	74.0 kDa

Format	Liquid 50mM Tris-HCl, pH 7.5, 150mM NaCl, 10mM glutathione, 0.1mM EDTA, 0.25mM DTT, 0.1mM PMSF, 25% glycerol.
Purity	70% - 90%
Storage	Store product at –70°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.

Immunogen Species	Homo Sapiens (Human)

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SKU	Supplier No.	Size	Your price	Quantity
BHP10900773	Z500378	10µg	$361.11		Add to Cart

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