Recombinant Human T-cell surface glycoprotein CD8 alpha chain(CD8A),partial

Mfr.No.	CSB-YP004966HU
Description	Identifies cytotoxic/suppressor T-cells that interact with MHC class I bearing targets. CD8 is thought to play a role in the process of T-cell mediated killing. CD8 alpha chains binds to class I MHC molecules alpha-3 domains.
Alternative Names	T-lymphocyte differentiation antigen T8/Leu-2, CD_antigen: CD8a, T-lymphocyte differentiation antigen T8/Leu-2 CD_antigen: CD8a
Tag	N-terminal 6xHis-tagged
Regulatory	RUO
Relevance	Identifies cytotoxic/suppressor T-cells that interact with MHC class I bearing targets. CD8 is thought to play a role in the process of T-cell mediated killing. CD8 alpha chains binds to class I MHC molecules alpha-3 domains.
Source	Yeast
Notes	Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Protein Name	Recommended name: T-cell surface glycoprotein CD8 alpha chain; Alternative name(s): T-lymphocyte differentiation antigen T8/Leu-2; CD_antigen= CD8a
Expression Region	22-182aa
Mol Weight	19.6kDa
Nature	Recombinant
Protein Description	Partial

Involvement In Disease	CD8 deficiency, familial (CD8 deficiency)
Subcellular Location	Isoform 1: Cell membrane, Single-pass type I membrane protein
Uniprot	P01732, P01732
Database Links	HGNC:1706 OMIM:186910 KEGG:hsa:925 STRING:9606.ENSP00000283635 UniGene:Hs.85258
Function	Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class I molecule
Pathway	Antigen processing and presentation; Hematopoietic cell lineage; T cell receptor signaling pathway
Research Area	Immunology
Tissue Specificity	CD8 on thymus-derived T-cells usually consists of a disulfide-linked alpha/CD8A and a beta/CD8B chain. Less frequently, CD8 can be expressed as a CD8A homodimer. A subset of natural killer cells, memory T-cells, intraepithelial lymphocytes, monocytes and
Weight	19.6 kDa

Stotage Note	Repeated freezing and thawing is not recommended. Store working aliquots at 4℃ for up to one week.
Buffer	Tris-based buffer，50% glycerol
Purity	Greater than 90% as determined by SDS-PAGE.
Storage	The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Storage Buffer	Tris-based buffer,50% glycerol