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Home / Proteins & Peptide

Recombinant Human SWI/SNF complex subunit SMARCC1(SMARCC1) ,partial

SKU : BHP10503968

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CUSABIO TECHONOLOGY LLC

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Mfr.No.	CSB-BP821715HU
Alternative Names	BRG1-associated factor 155 ,BAF155SWI/SNF complex 155 kDa subunitSWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily C member 1, BRG1-associated factor 155 ; BAF155SWI/SNF complex 155 kDa subunitSWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily C member 1
Tag	N-terminal 6xHis-tagged
Regulatory	RUO
Relevance	Involved in transcriptional activation and repression of select genes by chromatin rodeling (alteration of DNA-nucleosome topology). May stimulate the ATPase activity of the catalytic subunit of the complex. Belongs to the neural progenitors-specific chromatin rodeling complex (npBAF complex) and the neuron-specific chromatin rodeling complex (nBAF complex). During neural development a switch from a st/progenitor to a post-mitotic chromatin rodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural st/progenitor cells to post-mitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural st cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth .
Source	Baculovirus
Notes	Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Expression Region	449-669aa
Mol Weight	27.4kDa
Nature	recombinant
Protein Description	Partial

Subcellular Location	Nucleus, Cytoplasm
Uniprot	Q92922, Q92922
Database Links	HGNC:11104 OMIM:601732 KEGG:hsa:6599 STRING:9606.ENSP00000254480 UniGene:Hs.476179
Function	Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner. May stimulate the ATPase activity of the catalytic subunit of the complex
Protein Families	SMARCC family
Research Area	Neuroscience
Tissue Specificity	Expressed in brain, heart, muscle, placenta, lung, liver, muscle, kidney and pancreas.
Weight	18.9kDa

Stotage Note	Repeated freezing and thawing is not recommended. Store working aliquots at 4℃ for up to one week.
Buffer	Tris-based buffer，50% glycerol
Purity	Greater than 90% as determined by SDS-PAGE.
Storage	The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Storage Buffer	Tris-based buffer,50% glycerol

Immunogen Species	Homo Sapiens (Human)

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SKU	Supplier No.	Size	Your price	Quantity
BHP10503968	CSB-BP821715HU	100ug	$1478		Add to Cart
BHP10503968	CSB-BP821715HU	20ug	$528		Add to Cart

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