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Home / Proteins & Peptide

Recombinant Human STK10/LOK Protein (His Tag)(Active)

SKU : BHP10302716

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Elabscience Biotechnology Co.,Ltd

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Mfr.No.	PKSH030352
Description	A DNA sequence encoding the human STK10 (NP_005981.3) (Arg 18-Glu 317) was expressed, with a polyhistide tag at the N-terminus.
Alternative Names	LOK;PRO2729
Reconstitution	Please refer to the printed manual for detailed information.
Background	Serine / threonine-protein kinase 10, also known as Lymphocyte-oriented kinase, STK10 and LOK, which belongs to the protein kinase superfamily, STE Ser / Thr protein kinase family and STE20 subfamily. Protein kinases constitute a large superfamily of enzymes with key regulatory functions in nearly all signal transmission processes of eukaryotic cells. The Ste20 family of serine/threonine kinases plays an important role in numerous cellular functions such as growth, apoptosis, and morphogenesis. STK10 is similar to several known polo-like kinase kinases. It can associate with and phosphorylate polo-like kinase 1, and overexpression of a kinase-dead version of the protein interferes with normal cell cycle progression. STK10 can also negatively regulate interleukin 2 expression in T-cells via the mitogen activated protein kinase kinase 1 pathway. Stk10 can associate with Plk1 in cells and furthermore can phosphorylate Plk1. It can also act on substrates such as myelin basic protein and histone 2A on serine and threonine residues.
Reactivity	Human
Tag	N-His
Formulation	Supplied as sterile 20mM Tris, 500mM NaCl, pH 8.0
Host	E.coli
Accession Number	NP_005981.3
Endotoxin Level	Please contact us for more information.
Bioactivity	The specific activity was determined to be 1353 nmol/min/mg using synthetic AXLtide peptide (KKSRGDYMTMQIG) as substrate.
Mol Weight	36 kDa
Mw(kda)	36 kDa

Sequence Info	Arg 18-Glu 317

Shipping	This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs.Upon receipt, store it immediately at<-20°C.
Stotage Note	Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.
Purity	> 95 % as determined by reducing SDS-PAGE.

Product Manual	Data Sheet

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SKU	Supplier No.	Size	Your price	Quantity
BHP10302716	PKSH030352	50ug	$717		Add to Cart

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