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Recombinant Human Squamous cell carcinoma antigen recognized by T-cells 3(SART3) ,partial

SKU : BHP10501326

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CUSABIO TECHONOLOGY LLC

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Mfr.No.	CSB-EP624010HU
Alternative Names	Tat-interacting protein of 110 kDa1
Antigen	SART3
Tag	N-terminal 6xHis-SUMO-tagged
Regulatory	RUO
Relevance	U6 snRNP-binding protein that functions as a recycling factor of the splicing machinery. Promotes the initial reassbly of U4 and U6 snRNPs following their ejection from the spliceosome during its maturation . Also binds U6atac snRNPs and may function as a recycling factor for U4atac/U6atac spliceosomal snRNP, an initial step in the assbly of U12-type spliceosomal complex. The U12-type spliceosomal complex plays a role in the splicing of introns with non-canonical splice sites . May also function as a substrate-targeting factor for deubiquitinases like USP4 and USP15. Recruits USP4 to ubiquitinated PRPF3 within the U4/U5/U6 tri-snRNP complex, promoting PRPF3 deubiquitination and thereby regulating the spliceosome U4/U5/U6 tri-snRNP spliceosomal complex disassbly . May also recruit the deubiquitinase USP15 to histone H2B and mediate histone deubiquitination, thereby regulating gene expression and/or DNA repair . May play a role in hatopoiesis probably through transcription regulation of specific genes including MYC .
Source	E.coli
Abbreviation	SART3
Notes	Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Protein Name	Recommended name: Squamous cell carcinoma antigen recognized by T-cells 3; Short name= SART-3; Short name= hSART-3; Alternative name(s): Tat-interacting protein of 110 kDa; Short name= Tip110
Expression Region	600-900aa
Mol Weight	49.8kDa
Nature	recombinant
Protein Description	Partial

Subcellular Location	Nucleus, nucleoplasm, Nucleus, Cajal body, Nucleus speckle, Cytoplasm
Uniprot	Q15020, Q15020
Database Links	HGNC:16860 OMIM:611684 KEGG:hsa:9733 STRING:9606.ENSP00000228284 UniGene:Hs.584842
Function	U6 snRNP-binding protein that functions as a recycling factor of the splicing machinery. Promotes the initial reassembly of U4 and U6 snRNPs following their ejection from the spliceosome during its maturation
Research Area	Cancer
Tissue Specificity	Ubiquitously expressed.
Weight	49.82kDa

Stotage Note	Repeated freezing and thawing is not recommended. Store working aliquots at 4℃ for up to one week.
Buffer	Tris-based buffer，50% glycerol
Purity	Greater than 90% as determined by SDS-PAGE.
Storage	The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Storage Buffer	Tris-based buffer,50% glycerol

Immunogen Species	Homo Sapiens (Human)

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SKU	Supplier No.	Size	Your price	Quantity
BHP10501326	CSB-EP624010HU	1mg	$1812		Add to Cart
BHP10501326	CSB-EP624010HU	100ug	$419		Add to Cart
BHP10501326	CSB-EP624010HU	20ug	$224		Add to Cart

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