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Home / Proteins & Peptide

Recombinant Human Splicing factor U2AF 26KDA subunit(U2AF1L4)

SKU : BHP10503766

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CUSABIO TECHONOLOGY LLC

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Mfr.No.	CSB-EP837850HU
Alternative Names	U2 auxiliary factor 26, U2 small nuclear RNA auxiliary factor 1-like protein 4, U2 auxiliary factor 26 ; U2 small nuclear RNA auxiliary factor 1-like protein 4
Tag	N-terminal GST-tagged
Regulatory	RUO
Relevance	RNA-binding protein that function as a pre-mRNA splicing factor. Plays a critical role in both constitutive and enhancer-dependent splicing by mediating protein-protein interactions and protein-RNA interactions required for accurate 3'-splice site selection. Acts by enhancing the binding of U2AF2 to weak pyrimidine tracts. Also participates in the regulation of alternative pre-mRNA splicing. Activates exon 5 skipping of PTPRC during T-cell activation; an event reversed by GFI1. Binds to RNA at the AG dinucleotide at the 3'-splice site. Shows a preference for AGC or AGA
Source	E.coli
Abbreviation	U2AF1L4
Notes	Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Protein Name	Recommended name: Splicing factor U2AF 26 kDa subunitAlternative name(s): U2 auxiliary factor 26 U2 small nuclear RNA auxiliary factor 1-like protein 4 U2(RNU2) small nuclear RNA auxiliary factor 1-like protein 3 Short name= U2 small nuc
Expression Region	1-202aa
Mol Weight	49.0kDa
Nature	recombinant
Protein Description	Full Length of Isoform 2

Subcellular Location	Nucleus, Nucleus speckle, Cytoplasm
Uniprot	Q8WU68, Q8WU68
Database Links	HGNC:23020 OMIM:601080 KEGG:hsa:199746 UniGene:Hs.351558
Function	RNA-binding protein that function as a pre-mRNA splicing factor. Plays a critical role in both constitutive and enhancer-dependent splicing by mediating protein-protein interactions and protein-RNA interactions required for accurate 3'-splice site selection. Acts by enhancing the binding of U2AF2 to weak pyrimidine tracts. Also participates in the regulation of alternative pre-mRNA splicing. Activates exon 5 skipping of PTPRC during T-cell activation; an event reversed by GFI1. Binds to RNA at the AG dinucleotide at the 3'-splice site (By similarity). Shows a preference for AGC or AGA (By similarity).
Protein Families	Splicing factor SR family
Research Area	Others
Tissue Specificity	Isoform 2 is widely expressed. Isoform 3 is highly expressed in heart, brain and lung, lower expressed in thymus and much lower expressed in peripheral blood leukocytes.
Weight	49.822kD

Stotage Note	Repeated freezing and thawing is not recommended. Store working aliquots at 4℃ for up to one week.
Buffer	Tris-based buffer，50% glycerol
Purity	Greater than 90% as determined by SDS-PAGE.
Storage	The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Storage Buffer	Tris-based buffer,50% glycerol

Immunogen Species	Homo Sapiens (Human)

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SKU	Supplier No.	Size	Your price	Quantity
BHP10503766	CSB-EP837850HU	1mg	$2466		Add to Cart
BHP10503766	CSB-EP837850HU	100ug	$578		Add to Cart
BHP10503766	CSB-EP837850HU	20ug	$306		Add to Cart

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