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Home / Proteins & Peptide

Recombinant Human Sorting nexin-3(SNX3)

SKU : BHP10501690

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CUSABIO TECHONOLOGY LLC

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Mfr.No.	CSB-RP013244h
Alternative Names	Protein SDP3
Tag	N-terminal GST-tagged
Regulatory	RUO
Relevance	Phosphoinositide-binding protein required for multivesicular body formation. Specifically binds phosphatidylinositol 3-phosphate (PtdIns(P3)). Also can bind phosphatidylinositol 4-phosphate (PtdIns(P4)), phosphatidylinositol 5-phosphate (PtdIns(P5)) and phosphatidylinositol 3,5-biphosphate (PtdIns(3,5)P2) . Plays a role in protein transport between cellular compartments. Together with RAB7A facilitates endosome mbrane association of the retromer cargo-selective subcomplex (CSC/VPS). May in part act as component of the SNX3-retromer complex which mediates the retrograde endosome-to-TGN transport of WLS distinct from the SNX-BAR retromer pathway . Promotes stability and cell surface expression of epithelial sodium channel (ENAC) subunits SCNN1A and SCNN1G . Not involved in EGFR degradation. Involved in the regulation of phagocytosis in dendritic cells possibly by regulating EEA1 recruitment to the nascent phagosomes . Involved in iron homeostasis through regulation of endocytic recycling of the transferrin receptor TFRC presumably by delivering the tranferrin:transferrin receptor complex to recycling endosomes; the function may involve the CSC retromer subcomplex . In the case of Salmonella enterica infection plays arole in maturation of the Salmonella-containing vacuole (SCV) and promotes recruitment of LAMP1 to SCVs .
Source	E.coli
Notes	Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Expression Region	3-162aa
Mol Weight	45.6kDa
Nature	recombinant
Protein Description	Full Length of Mature Protein

Involvement In Disease	Microphthalmia, syndromic, 8 (MCOPS8)
Subcellular Location	Early endosome, Cytoplasmic vesicle, phagosome
Uniprot	O60493, O60493
Database Links	HGNC:11174 OMIM:601349 KEGG:hsa:8724 STRING:9606.ENSP00000230085 UniGene:Hs.12102
Function	Phosphoinositide-binding protein required for multivesicular body formation. Specifically binds phosphatidylinositol 3-phosphate (PtdIns(P3)). Also can bind phosphatidylinositol 4-phosphate (PtdIns(P4)), phosphatidylinositol 5-phosphate (PtdIns(P5)) and phosphatidylinositol 3,5-biphosphate (PtdIns(3,5)P2) (By similarity). Plays a role in protein transport between cellular compartments. Together with RAB7A facilitates endosome membrane association of the retromer cargo-selective subcomplex (CSC/VPS). May in part act as component of the SNX3-retromer complex which mediates the retrograde endosome-to-TGN transport of WLS distinct from the SNX-BAR retromer pathway
Pathway	Endocytosis
Protein Families	Sorting nexin family
Research Area	Transport
Weight	45.9kDa

Stotage Note	Repeated freezing and thawing is not recommended. Store working aliquots at 4℃ for up to one week.
Buffer	Tris-based buffer，50% glycerol
Purity	Greater than 90% as determined by SDS-PAGE.
Storage	The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Storage Buffer	Tris-based buffer,50% glycerol

Immunogen Species	Homo Sapiens (Human)

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SKU	Supplier No.	Size	Your price	Quantity
BHP10501690	CSB-RP013244h	1mg	$1812		Add to Cart
BHP10501690	CSB-RP013244h	100ug	$419		Add to Cart
BHP10501690	CSB-RP013244h	20ug	$224		Add to Cart

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