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Home / Proteins & Peptide

Recombinant Human Single-strand selective monofunctional uracil DNA glycosylase(SMUG1)

SKU : BHP10501347

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CUSABIO TECHONOLOGY LLC

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Mfr.No.	CSB-EP706636HU
Tag	N-terminal 6xHis-SUMO-tagged
Regulatory	RUO
Relevance	Recognizes base lesions in the genome and initiates base excision DNA repair. Acts as a monofunctional DNA glycosylase specific for uracil (U) residues in DNA with a preference for single-stranded DNA substrates. The activity is greater toward mismatches (U/G) compared to matches (U/A). Excises uracil (U), 5-formyluracil (fU) and uracil derivatives bearing an oxidized group at C5 [5-hydroxyuracil (hoU) and 5-hydroxymethyluracil (hmU)] in ssDNA and dsDNA, but not analogous cytosine derivatives (5-hydroxycytosine and 5-formylcytosine), nor other oxidized bases. The activity is damage-specific and salt-dependent. The substrate preference is the following: ssDNA > dsDNA (G pair) = dsDNA (A pair) at low salt concentration, and dsDNA (G pair) > dsDNA (A pair) > ssDNA at high salt concentration.
Source	E.coli
Abbreviation	SMUG1
Notes	Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Protein Name	Recommended name: Single-strand selective monofunctional uracil DNA glycosylase; EC= 3.2.2.-
Expression Region	1-177aa
Mol Weight	35.6kDa
Nature	recombinant
Protein Description	Full Length of Isoform 2

Subcellular Location	Nucleus
Uniprot	Q53HV7, Q53HV7
Database Links	HGNC:17148 OMIM:607753 KEGG:hsa:23583 STRING:9606.ENSP00000338606 UniGene:Hs.632721
Function	Recognizes base lesions in the genome and initiates base excision DNA repair. Acts as a monofunctional DNA glycosylase specific for uracil (U) residues in DNA with a preference for single-stranded DNA substrates. The activity is greater toward mismatches (U/G) compared to matches (U/A). Excises uracil (U), 5-formyluracil (fU) and uracil derivatives bearing an oxidized group at C5 [5-hydroxyuracil (hoU) and 5-hydroxymethyluracil (hmU)] in ssDNA and dsDNA, but not analogous cytosine derivatives (5-hydroxycytosine and 5-formylcytosine), nor other oxidized bases. The activity is damage-specific and salt-dependent. The substrate preference is the following
Pathway	DNA repair pathway
Protein Families	Uracil-DNA glycosylase (UDG) superfamily, SMUG1 family
Research Area	Epigenetics and Nuclear Signaling
Weight	35.61kDa

Stotage Note	Repeated freezing and thawing is not recommended. Store working aliquots at 4℃ for up to one week.
Buffer	Tris-based buffer，50% glycerol
Purity	Greater than 90% as determined by SDS-PAGE.
Storage	The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Storage Buffer	Tris-based buffer,50% glycerol

Immunogen Species	Homo Sapiens (Human)

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SKU	Supplier No.	Size	Your price	Quantity
BHP10501347	CSB-EP706636HU	1mg	$1812		Add to Cart
BHP10501347	CSB-EP706636HU	100ug	$419		Add to Cart
BHP10501347	CSB-EP706636HU	20ug	$224		Add to Cart

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