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Home / Proteins & Peptide

Recombinant Human SGK3/SGKL Protein (His & GST Tag)

SKU : BHP10302867

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Elabscience Biotechnology Co.,Ltd

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Mfr.No.	PKSH031020
Description	A DNA sequence encoding the human SGK3 (Q96BR1-1) (Met 1-Leu 496) was fused with the N-terminal polyhistidine-tagged GST tag at the N-terminus.
Alternative Names	CISK;SGK2;SGKL
Reconstitution	Please refer to the printed manual for detailed information.
Background	Serine / threonine-protein kinase Sgk3, also known as Serum / glucocorticoid-regulated kinase 3, Serum / glucocorticoid-regulated kinase-like and SGK3, is a cytoplasmic vesicle protein which belongs to the protein kinase superfamily and AGC Ser/Thr protein kinase family. SGK3 contains one AGC-kinase C-terminal domain, one protein kinase domain and one PX (phox homology) domain. Two specific sites of SGK3, one in the kinase domain (Thr-320) and the other in the C-terminal regulatory region (Ser-486), is needed to be phosphorylated for its full activation. SGK3 is expressed in most tissues with highest levels in pancreas, kidney liver, heart and brain and lower levels in lung, placenta and skeletal muscle. SGK3 is involved in the activation of potassium channels. It mediates cell IL-3-dependent survival signals. SGK3 participates in the regulation of HERG by increasing HERG protein abundance in the plasma membrane and may thus modify the duration of the cardiac action potential. SGK3 is also a very important and characteristic molecule that plays a critical role in both hair follicle morphogenesis and hair cycling.
Reactivity	Human
Tag	N-His & GST
Formulation	Lyophilized from sterile 20mM Tris, 500mM NaCl, 0.5mM PMSF, 10% gly, 1mM GSH, pH 7.4
Host	Baculovirus-Insect Cells
Accession Number	Q96BR1-1
Endotoxin Level	< 1.0 EU per ug as determined by the LAL method.
Mol Weight	85 kDa
Mw(kda)	85 kDa

Sequence Info	Met 1-Leu 496

Shipping	This product is provided as lyophilized powder which is shipped with ice packs.
Stotage Note	Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
Purity	> 80 % as determined by reducing SDS-PAGE.

Product Manual	Data Sheet

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SKU	Supplier No.	Size	Your price	Quantity
BHP10302867	PKSH031020	50ug	$486		Add to Cart

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