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Recombinant Human Serine/threonine-protein kinase STK11(STK11)

SKU : BHP10501329

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CUSABIO TECHONOLOGY LLC

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Mfr.No.	CSB-EP624036HU
Alternative Names	Liver kinase B1 ,LKB1 ,hLKB1Renal carcinoma antigen NY-REN-19, Liver kinase B1 ; LKB1 ; hLKB1Renal carcinoma antigen NY-REN-19
Tag	N-terminal 6xHis-SUMO-tagged
Regulatory	RUO
Relevance	Tumor suppressor serine/threonine-protein kinase that controls the activity of AMP-activated protein kinase (AMPK) family mbers, thereby playing a role in various processes such as cell metabolism, cell polarity, apoptosis and DNA damage response. Acts by phosphorylating the T-loop of AMPK family proteins, thus promoting their activity: phosphorylates PRKAA1, PRKAA2, BRSK1, BRSK2, MARK1, MARK2, MARK3, MARK4, NUAK1, NUAK2, SIK1, SIK2, SIK3 and SNRK but not MELK. Also phosphorylates non-AMPK family proteins such as STRADA, PTEN and possibly p53/TP53. Acts as a key upstream regulator of AMPK by mediating phosphorylation and activation of AMPK catalytic subunits PRKAA1 and PRKAA2 and thereby regulates processes including: inhibition of signaling pathways that promote cell growth and proliferation when energy levels are low, glucose homeostasis in liver, activation of autophagy when cells undergo nutrient deprivation, and B-cell differentiation in the germinal center in response to DNA damage. Also acts as a regulator of cellular polarity by rodeling the actin cytoskeleton. Required for cortical neuron polarization by mediating phosphorylation and activation of BRSK1 and BRSK2, leading to axon initiation and specification. Involved in DNA damage response: interacts with p53/TP53 and recruited to the CDKN1A/WAF1 promoter to participate in transcription activation. Able to phosphorylate p53/TP53; the relevance of such result in vivo is however unclear and phosphorylation may be indirect and mediated by downstream STK11/LKB1 kinase NUAK1. Also acts as a mediator of p53/TP53-dependent apoptosis via interaction with p53/TP53: translocates to the mitochondrion during apoptosis and regulates p53/TP53-dependent apoptosis pathways. In vein endothelial cells, inhibits PI3K/Akt signaling activity and thus induces apoptosis in response to the oxidant peroxynitrite (in vitro). Regulates UV radiation-induced DNA damage response mediated by CDKN1A. In association with NUAK1, phosphorylates CDKN1A in response to UV radiation and contributes to its degradation which is necessary for optimal DNA repair
Source	E.coli
Notes	Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Expression Region	1-430aa
Mol Weight	64.3kDa
Nature	recombinant
Protein Description	Full Length of Mature Protein

Involvement In Disease	Peutz-Jeghers syndrome (PJS); Testicular germ cell tumor (TGCT)
Subcellular Location	Nucleus, Cytoplasm, Membrane, Mitochondrion, Note=A small fraction localizes at membranes (By similarity), Relocates to the cytoplasm when bound to STRAD (STRADA or STRADB) and CAB39/MO25 (CAB39/MO25alpha or CAB39L/MO25beta), Translocates to the mitochondrion during apoptosis, Translocates to the cytoplasm in response to metformin or peroxynitrite treatment, PTEN promotes cytoplasmic localization, SUBCELLULAR LOCATION: Isoform 2: Nucleus, Cytoplasm
Uniprot	Q15831, Q15831
Database Links	HGNC:11389 OMIM:175200 KEGG:hsa:6794 STRING:9606.ENSP00000324856 UniGene:Hs.515005
Function	Tumor suppressor serine/threonine-protein kinase that controls the activity of AMP-activated protein kinase (AMPK) family members, thereby playing a role in various processes such as cell metabolism, cell polarity, apoptosis and DNA damage response. Acts by phosphorylating the T-loop of AMPK family proteins, thus promoting their activity
Pathway	mTOR signaling pathway; PI3K-Akt signaling pathway; Autophagy; MAPK Erk pathway; Adipocytokine signaling pathway; AMPK signaling; FoxO signaling pathway
Protein Families	Protein kinase superfamily, CAMK Ser/Thr protein kinase family, LKB1 subfamily
Research Area	Apoptosis
Tissue Specificity	Ubiquitously expressed. Strongest expression in testis and fetal liver.
Weight	64.1kDa

Stotage Note	Repeated freezing and thawing is not recommended. Store working aliquots at 4℃ for up to one week.
Buffer	Tris-based buffer，50% glycerol
Purity	Greater than 90% as determined by SDS-PAGE.
Storage	The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Storage Buffer	Tris-based buffer,50% glycerol

Immunogen Species	Homo Sapiens (Human)

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SKU	Supplier No.	Size	Your price	Quantity
BHP10501329	CSB-EP624036HU	1mg	$1812		Add to Cart
BHP10501329	CSB-EP624036HU	100ug	$419		Add to Cart
BHP10501329	CSB-EP624036HU	20ug	$224		Add to Cart

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