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Home / Proteins & Peptide

Recombinant Human Secreted Ly-6/uPAR domain-containing protein 2(SLURP2)

SKU : BHP10505409

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CUSABIO TECHONOLOGY LLC

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Mfr.No.	CSB-YP861187HU2
Description	Binds and may modulate the functional properties of nicotinic and muscarinic acetylcholine receptors. May regulate keratinocytes proliferation, differentiation and apoptosis. In vitro moderately inhibits ACh-evoked currents of alpha-3:beta-2-containing nAChRs and strongly these of alpha-4:beta-2-containing nAChRs, modulates alpha-7-containing nAChRs, and inhibits nicotine-induced signaling probably implicating alpha-3:beta-4-containing nAChRs. Proposed to act on alpha-3:beta-2 and alpha-7 nAChRs in an orthosteric, and on mAChRs, such as CHRM1 and CHRM3, in an allosteric manner.
Alternative Names	Secreted LY6/PLAUR domain-containing protein 2 Secreted Ly-6/uPAR-related protein 2
Tag	N-terminal 6xHis-tagged
Regulatory	RUO
Relevance	Binds and may modulate the functional properties of nicotinic and muscarinic acetylcholine receptors. May regulate keratinocytes proliferation, differentiation and apoptosis. In vitro moderately inhibits ACh-evoked currents of alpha-3:beta-2-containing nAChRs and strongly these of alpha-4:beta-2-containing nAChRs, modulates alpha-7-containing nAChRs, and inhibits nicotine-induced signaling probably implicating alpha-3:beta-4-containing nAChRs. Proposed to act on alpha-3:beta-2 and alpha-7 nAChRs in an orthosteric, and on mAChRs, such as CHRM1 and CHRM3, in an allosteric manner.
Source	Yeast
Notes	Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Protein Name	Secreted LY6/PLAUR domain-containing protein 2; Secreted Ly-6/uPAR-related protein 2
Expression Region	23-97aa
Mol Weight	10.0 kDa
Nature	Recombinant
Protein Description	Full Length of Mature Protein

Subcellular Location	Secreted
Uniprot	P0DP57, P0DP57
Database Links	HGNC:25549 OMIM:606110 KEGG:hsa:432355 UniGene:Hs.158665
Function	Binds and may modulate the functional properties of nicotinic and muscarinic acetylcholine receptors. May regulate keratinocytes proliferation, differentiation and apoptosis. In vitro moderately inhibits ACh-evoked currents of alpha-3
Research Area	Others
Tissue Specificity	Expressed at highest levels in cervix and esophagus, followed by adult and fetal skin. Expressed at lower levels in brain, lung, stomach, small intestine, colon, rectum, uterus, and thymus. Not detected in spleen nor bone marrow. Up-regulated 3-fold in ps
Weight	10 kDa

Stotage Note	Repeated freezing and thawing is not recommended. Store working aliquots at 4℃ for up to one week.
Buffer	Tris-based buffer，50% glycerol
Purity	Greater than 90% as determined by SDS-PAGE.
Storage	The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Storage Buffer	Tris-based buffer，50% glycerol

Immunogen Species	Homo Sapiens (Human)

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SKU	Supplier No.	Size	Your price	Quantity
BHP10505409	CSB-YP861187HU2	100ug	$694		Add to Cart
BHP10505409	CSB-YP861187HU2	20ug	$368		Add to Cart

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