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Applied Biological Materials (abm) Inc.
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Applied Biological Materials (abm) Inc.
view supplier detailsCredit card payments now incur a 3% fee.
| Mfr.No. | Z101837 |
| Description | CD23 is a calcium dependent transmembrane glycoprotein which is expressed in many cell types. The cytoplasmic region of the protein has two isoforms the 'a' isoform that participates in IgE-regulated endocytosis, and the 'b' isoform, which is involved in IgE-regulated phagocytosis. It has been found that there are at least four soluble forms of the CD23 protein (sCD23) all of which are produced by the activity of metallo/cysteine proteases. In addition to binding IgE, sCD23 have been shown to promote the activation and differentiation of B-cells and stimulate the release of pro-inflammatory cytokines from monocytes. |
| Alternative Names | Low affinity immunoglobulin epsilon Fc receptor ; BLAST-2 ; Fc-epsilon-RII ; Immunoglobulin E-binding factor ; Lymphocyte IgE receptor ; CD23 ; B cell differentiation antigen Recombinant Human C-type Lectin Domain Family 4 Member J (FCER2) |
| Appearance | Lyophilized Powder |
| Reconstitution | Reconstitute at 100 µg/mL in sterile PBS |
| Formulation | Lyophilized from a 0.2 µm filtered solution in PBS |
| Molecular Weight | 19.5 kDa |
| Quantity | 100 µg |
| Source | E. coli |
| Usage | For research use only. Not for diagnostic or therapeutic use. |
| Accession Number | P06734 |
| Endotoxin Level | <1.0 EU/μg of recombinant protein as determined by the LAL method. |
| Bioactivity | Measured by its ability to bind in a functional ELISA. Immobilized rhCD23 at 2 µg/mL (100 µL/well) can bind human IgE with a linear range of 0.0151 µg/mL. |
| Gel Image | -Z101835-1.png)
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