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Home / Proteins & Peptide

Recombinant Human Sarcoplasmic/endoplasmic reticulum calcium ATPase 2(ATP2A2),partial

SKU : BHP10500344

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CUSABIO TECHONOLOGY LLC

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Mfr.No.	CSB-EP002333HU
Alternative Names	Calcium pump 2,Calcium-transporting ATPase sarcoplasmic reticulum type, slow twitch skeletal muscle isoform,Endoplasmic reticulum class 1/2 Ca(2+) ATPase, Calcium pump 2 ; Calcium-transporting ATPase sarcoplasmic reticulum type, slow twitch skeletal muscle isoform ; Endoplasmic reticulum class 1/2 Ca(2+) ATPase
Antigen	ATP2A2
Tag	N-terminal 6xHis-tagged
Regulatory	RUO
Relevance	This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the translocation of calcium from the cytosol to the sarcoplasmic reticulum lumen. Isoform 2 is involved in the regulation of the contraction/relaxation cycle.
Source	E.coli
Notes	Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Protein Name	Recommended name: Sarcoplasmic/endoplasmic reticulum calcium ATPase 2 Short name= SERCA2 Short name= SR Ca(2+)-ATPase 2 EC= 3.6.3.8Alternative name(s): Calcium pump 2 Calcium-transporting ATPase sarcoplasmic reticulum type, slow
Expression Region	314-756aa
Mol Weight	52.3kDa
Nature	recombinant
Protein Description	Partial

Involvement In Disease	Acrokeratosis verruciformis (AKV); Darier disease (DD)
Subcellular Location	Endoplasmic reticulum membrane, Multi-pass membrane protein, Sarcoplasmic reticulum membrane, Multi-pass membrane protein
Uniprot	P16615, P16615
Database Links	HGNC:812 OMIM:101900 KEGG:hsa:488 STRING:9606.ENSP00000440045 UniGene:Hs.506759
Function	This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the translocation of calcium from the cytosol to the sarcoplasmic reticulum lumen. Isoform 2 is involved in the regulation of the contraction/relaxation cycle
Pathway	Calcium signaling pathway; cAMP signaling pathway; Cardiac muscle contraction; cGMP-PKG signaling pathway
Protein Families	Cation transport ATPase (P-type) (TC 3.A.3) family, Type IIA subfamily
Research Area	Cardiovascular
Tissue Specificity	Isoform 1 is widely expressed in smooth muscle and nonmuscle tissues such as in adult skin epidermis, with highest expression in liver, pancreas and lung, and intermediate expression in brain, kidney and placenta. Also expressed at lower levels in heart a
Weight	52.42kDa

Stotage Note	Repeated freezing and thawing is not recommended. Store working aliquots at 4℃ for up to one week.
Buffer	Tris-based buffer，50% glycerol
Purity	Greater than 90% as determined by SDS-PAGE.
Storage	The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Storage Buffer	Tris-based buffer,50% glycerol

Immunogen Species	Homo Sapiens (Human)

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SKU	Supplier No.	Size	Your price	Quantity
BHP10500344	CSB-EP002333HU	1mg	$1812		Add to Cart
BHP10500344	CSB-EP002333HU	100ug	$419		Add to Cart
BHP10500344	CSB-EP002333HU	20ug	$224		Add to Cart

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