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Home / Proteins & Peptide

Recombinant Human ROR1 Protein (aa 453-783, His & GST Tag)(Active)

SKU : BHP10302708

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Elabscience Biotechnology Co.,Ltd

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Mfr.No.	PKSH030321
Alternative Names	dJ537F10.1;NTRKR1
Reconstitution	Please refer to the printed manual for detailed information.
Background	Receptor tyrosine kinase-like orphan receptor 1 (ROR1), also known as neurotrophic tyrosine kinase, it is a member of the ROR family within receptor tyrosine kinases (RTK) superfamily. Human ROR1 is a type I transmembrane protein with 937 amino acids (aa) in length. It contains a 29 aa signal sequence, a 377 aa extracellular domain (ECD), a 21 aa transmembrane segment, and a 510 aa cytoplasmic region. ROR1 expressed strongly in human heart, lung and kidney, but weakly in the CNS. At developmental stage, it expressed at high levels during early embryonic development. ROR1 has been shown to have very low kinase activity in vitro and is unlikely to function as a tyrosine kinase in vivo. It may act as a receptor for wnt ligand WNT5A which may result in the inhibition of WNT3A-mediated signaling.
Reactivity	Human
Tag	N-His & GST
Description	A DNA sequence encoding the human ROR1 (AAA60275.1) (Met453-Asn783) was fused with the N-terminal polyhistidine-tagged GST tag at the N-terminus.
Formulation	Supplied as sterile 20mM Tris, 500mM NaCl, 2mM GSH, 3mM DTT, 10% glycerol, pH 7.4
Host	Baculovirus-Insect Cells
Accession Number	AAA60275.1
Endotoxin Level	< 1.0 EU per ug as determined by the LAL method.
Bioactivity	The specific activity was determined to be 0.3 nmol/min/mg using MBP as substrate.
Mol Weight	65.3 kDa
Mw(kda)	65.3 kDa

Sequence Info	Met 453-Asn783

Shipping	This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs.Upon receipt, store it immediately at<-20°C.
Stotage Note	Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.
Purity	> 90 % as determined by reducing SDS-PAGE.

Product Manual	Data Sheet

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SKU	Supplier No.	Size	Your price	Quantity
BHP10302708	PKSH030321	50ug	$717		Add to Cart

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