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Home / Proteins & Peptide

Recombinant Human RNF43 Protein (His Tag)

SKU : BHP10302753

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Elabscience Biotechnology Co.,Ltd

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Mfr.No.	PKSH030501
Description	A DNA sequence encoding the human RNF43 (NP_060233.3) (Met1-Tyr197) was expressed with a polyhistidine tag at the C-terminus.
Alternative Names	RNF124;RNF43;URCC
Reconstitution	Please refer to the printed manual for detailed information.
Background	RING finger protein 43 (RNF43) is a 90 kDa member of the ZNRF3 family of ubiquitin ligase proteins. Human RNF43 is synthesized as a 783 amino acid (aa) protein that contains a putative 23 aa signal sequence, a 174 aa extracellular domain (ECD), a transmembrane domain, and a cytoplasmic domain with an atypical RING-type zinc finger. RNF43 is expressed in stem cells at the bottom of colon crypts, where it limits the ability of Wnts to induce proliferation. RNF43 and ZNRF3, another transmembrane E3 ubiquitin ligase, ubiquitinate and promote the turnover of Frizzled Wnt receptors to antagonize Wnt signaling. RNF43 has been shown to suppress both canonical and non-canonical Wnt signaling pathways by distinct mechanisms. RNF43/ZNRF3-mediated turnover of Frizzled receptors is inhibited by R-Spondin. Dishevelled, a positive regulator of Wnt signaling, interacts with RNF43/ZNRF3 to mediate turnover of Frizzled receptors. RNF43 may promote cell survival by binding to NEDL1 and by suppressing the transcriptional activity of p53. RNF43 has been shown both to inhibit and promote cancer. Deletion of RNF43, as well as mutations found in colorectal and other cancers, allows hypersensitivity to Wnts and promotes adenoma formation. Furthermore, RNF43 down-regulation in gliomas is associated with poor prognosis. However, RNF43 is frequently over-expressed in cancers, correlating with growth-promoting activity and colorectal and hepatocellular cancer pathogenesis.
Reactivity	Human
Tag	C-His
Formulation	Lyophilized from sterile PBS, pH 7.4
Host	HEK293 Cells
Accession Number	NP_060233.3
Endotoxin Level	< 1.0 EU per ug of the protein as determined by the LAL method.
Mol Weight	20.5 kDa
Mw(kda)	20.5 kDa

Sequence Info	Met 1-Tyr197

Shipping	This product is provided as lyophilized powder which is shipped with ice packs.
Stotage Note	Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
Purity	(85.4+12.5) % as determined by reducing SDS-PAGE.

Product Manual	Data Sheet

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SKU	Supplier No.	Size	Your price	Quantity
BHP10302753	PKSH030501	100ug	$732		Add to Cart

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