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Home / Proteins & Peptide

Recombinant Human Rho GTPase-activating protein 19(ARHGAP19)

SKU : BHP10501325

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CUSABIO TECHONOLOGY LLC

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Mfr.No.	CSB-EP623954HU
Alternative Names	BRG1-associated factor 47 ,BAF47Integrase interactor 1 protein,SNF5 homolog ,hSNF5, BRG1-associated factor 47 ; BAF47Integrase interactor 1 protein ; SNF5 homolog ; hSNF5
Tag	N-terminal 6xHis-SUMO-tagged
Regulatory	RUO
Relevance	Core component of the BAF (hSWI/SNF) complex. This ATP-dependent chromatin-rodeling complex plays important roles in cell proliferation and differentiation, in cellular antiviral activities and inhibition of tumor formation. The BAF complex is able to create a stable, altered form of chromatin that constrains fewer negative supercoils than normal. This change in supercoiling would be due to the conversion of up to one-half of the nucleosomes on polynucleosomal arrays into asymmetric structures, termed altosomes, each composed of 2 histones octamers. Stimulates in vitro the rodeling activity of SMARCA4/BRG1/BAF190A. Involved in activation of CSF1 promoter. Belongs to the neural progenitors-specific chromatin rodeling complex (npBAF complex) and the neuron-specific chromatin rodeling complex (nBAF complex). During neural development a switch from a st/progenitor to a post-mitotic chromatin rodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural st/progenitor cells to post-mitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural st cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth . Plays a key role in cell-cycle control and causes cell cycle arrest in G0/G1.
Source	E.coli
Notes	Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Expression Region	1-494aa
Mol Weight	60.1kDa
Nature	recombinant
Protein Description	Full Length

Subcellular Location	Nucleus
Uniprot	Q12824, Q14CB8
Database Links	HGNC:23724 OMIM:611587 KEGG:hsa:84986 STRING:9606.ENSP00000351333 UniGene:Hs.80305
Function	GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state.
Research Area	Cell Cycle
Tissue Specificity	Strong expression in fetal heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas. Weak expression in adult pancreas, spleen, thymus, and ovary.
Weight	71.7kDa

Stotage Note	Repeated freezing and thawing is not recommended. Store working aliquots at 4℃ for up to one week.
Buffer	Tris-based buffer，50% glycerol
Purity	Greater than 90% as determined by SDS-PAGE.
Storage	The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Storage Buffer	Tris-based buffer,50% glycerol

Immunogen Species	Homo Sapiens (Human)

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SKU	Supplier No.	Size	Your price	Quantity
BHP10501325	CSB-EP623954HU	1mg	$1812		Add to Cart
BHP10501325	CSB-EP623954HU	100ug	$419		Add to Cart
BHP10501325	CSB-EP623954HU	20ug	$224		Add to Cart

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