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Home / Proteins & Peptide

Recombinant Human Receptor Tyrosine-Protein Kinase ErbB-2/HER2 (C-Fc-Avi) Biotinylated

SKU : BHP10304897

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Elabscience Biotechnology Co.,Ltd

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Mfr.No.	PKSH033959
Description	Biotinylated Recombinant Human Receptor tyrosine-protein kinase ErbB-2 is produced by our Mammalian expression system and the target gene encoding Thr23-Thr652 is expressed with a Fc, Avi tag at the C-terminus.
Alternative Names	Receptor tyrosine-protein kinase erbB-2; Metastatic lymph node gene 19 protein; Proto-oncogene Neu; Tyrosine kinase-type cell surface receptor HER2; ERBB2; MLN19; NGL; TKR1
Reconstitution	Please refer to the printed manual for detailed information.
Background	Human epidermal growth factor receptor 2 (HER2) is a type of membrane glycoprotein, and belongs to the epidermal growth factor (EGF) receptor family. HER2 plays a key role in development, cell proliferation and differentiation. HER2 has been reported to associate with malignancy and a poor prognosis in numerous carcinomas, including breast, prostate, ovarian, lung cancers and so on. HER2 is activated by dimerization and not activated by EGF, TGF-alpha and amphiregulin. Interaction with PTK6 increases its intrinsic kinase activity.It is heterodimer with EGFR, ERBB3 and ERBB4. HER2 associates with the 5'-TCAAATTC-3' sequence in the PTGS2/COX-2 promoter and activates its transcription. It implicated in transcriptional activation of CDKN1A and the function of the protein involves STAT3 and SRC. And also it involved in the transcription of rRNA genes by RNA Pol I and enhances protein synthesis and cell growth.
Reactivity	Human
Tag	C-Fc-Avi
Formulation	Lyophilized from a 0.2 um filtered solution of PBS, pH 7.4.
Host	Human Cells
Accession Number	P04626
Endotoxin Level	< 1.0 EU per ug as determined by the LAL method.
Mol Weight	98.3 kDa
Mw(kda)	98.3 kDa

Sequence Info	Thr23-Thr652

Shipping	This product is provided as lyophilized powder which is shipped with ice packs.
Stotage Note	Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
Purity	>90% as determined by reducing SDS-PAGE.

Product Manual	Data Sheet

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SKU	Supplier No.	Size	Your price	Quantity
BHP10304897	PKSH033959	20ug	$342		Add to Cart
BHP10304897	PKSH033959	100ug	$924		Add to Cart

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