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Home / Proteins & Peptide

Recombinant Human Receptor-type tyrosine-protein phosphatase C(PTPRC),partial

SKU : BHP10503901

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CUSABIO TECHONOLOGY LLC

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Mfr.No.	CSB-EP019049HU
Alternative Names	Leukocyte common antigen
Antigen	PTPRC
Tag	N-terminal 6xHis-SUMO-tagged
Regulatory	RUO
Relevance	Protein tyrosine-protein phosphatase required for T-cell activation through the antigen receptor. Acts as a positive regulator of T-cell coactivation upon binding to DPP4. The first PTPase domain has enzymatic activity, while the second one seems to affect the substrate specificity of the first one. Upon T-cell activation, recruits and dephosphorylates SKAP1 and FYN. Dephosphorylates LYN, and thereby modulates LYN activity
Source	E.coli
Notes	Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Protein Name	Recommended name: Receptor-type tyrosine-protein phosphatase C; EC= 3.1.3.48; Alternative name(s): Leukocyte common antigen; Short name= L-CA; T200; CD_antigen= CD45
Expression Region	24-575aa
Mol Weight	76.8kDa
Nature	recombinant
Protein Description	Partial

Involvement In Disease	Severe combined immunodeficiency autosomal recessive T-cell-negative/B-cell-positive/NK-cell-positive (T(-)B(+)NK(+) SCID); Multiple sclerosis (MS)
Subcellular Location	Membrane, Single-pass type I membrane protein, Membrane raft
Uniprot	P08575, P08575
Database Links	HGNC:9666 OMIM:126200 KEGG:hsa:5788 STRING:9606.ENSP00000356346 UniGene:Hs.654514
Function	Protein tyrosine-protein phosphatase required for T-cell activation through the antigen receptor. Acts as a positive regulator of T-cell coactivation upon binding to DPP4. The first PTPase domain has enzymatic activity, while the second one seems to affect the substrate specificity of the first one. Upon T-cell activation, recruits and dephosphorylates SKAP1 and FYN. Dephosphorylates LYN, and thereby modulates LYN activity (By similarity).
Pathway	Fc gamma R-mediated phagocytosis; T cell receptor signaling pathway
Protein Families	Protein-tyrosine phosphatase family, Receptor class 1/6 subfamily
Research Area	Immunology
Weight	77.27kDa

Stotage Note	Repeated freezing and thawing is not recommended. Store working aliquots at 4℃ for up to one week.
Buffer	Tris-based buffer，50% glycerol
Purity	Greater than 90% as determined by SDS-PAGE.
Storage	The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Storage Buffer	Tris-based buffer,50% glycerol

Immunogen Species	Homo Sapiens (Human)

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SKU	Supplier No.	Size	Your price	Quantity
BHP10503901	CSB-EP019049HU	1mg	$1812		Add to Cart
BHP10503901	CSB-EP019049HU	100ug	$419		Add to Cart
BHP10503901	CSB-EP019049HU	20ug	$224		Add to Cart

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