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Home / Proteins & Peptide

Recombinant Human Ras association domain-containing protein 5(RASSF5)

SKU : BHP10503753

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CUSABIO TECHONOLOGY LLC

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Mfr.No.	CSB-EP819906HU
Alternative Names	New ras effector 1, Regulator for cell adhesion and polarization enriched in lymphoid tissues, New ras effector 1 ; Regulator for cell adhesion and polarization enriched in lymphoid tissues
Tag	N-terminal GST-tagged
Regulatory	RUO
Relevance	Potential tumor suppressor. Seems to be involved in lymphocyte adhesion by linking RAP1A activation upon T-cell receptor or chemokine stimulation to integrin activation. Isoform 2 stimulates lymphocyte polarization and the patch-like distribution of ITGAL/LFA-1, resulting in an enhanced adhesion to ICAM1. Together with RAP1A may participate in regulation of microtubule growth. The association of isoform 2 with activated RAP1A is required for directional movement of endothelial cells during wound healing. May be involved in regulation of Ras apoptotic function. The RASSF5-STK4/MST1 complex may mediate HRAS and KRAS induced apoptosis.
Source	E.coli
Abbreviation	RASSF5
Notes	Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Protein Name	Recommended name: Ras association domain-containing protein 5Alteative name(s): New ras effector 1 Regulator for cell adhesion and polarization enriched in lymphoid tissues Short name= RAPL
Expression Region	1-265aa
Mol Weight	57.4kDa
Nature	recombinant
Protein Description	Full Length of Isoform 2

Subcellular Location	Cytoplasm, Cytoplasm, cytoskeleton
Uniprot	Q8WWW0, Q8WWW0
Database Links	HGNC:17609 OMIM:607020 KEGG:hsa:83593 STRING:9606.ENSP00000347443 UniGene:Hs.497579
Function	Potential tumor suppressor. Seems to be involved in lymphocyte adhesion by linking RAP1A activation upon T-cell receptor or chemokine stimulation to integrin activation. Isoform 2 stimulates lymphocyte polarization and the patch-like distribution of ITGAL/LFA-1, resulting in an enhanced adhesion to ICAM1. Together with RAP1A may participate in regulation of microtubule growth. The association of isoform 2 with activated RAP1A is required for directional movement of endothelial cells during wound healing. May be involved in regulation of Ras apoptotic function. The RASSF5-STK4/MST1 complex may mediate HRAS and KRAS induced apoptosis.
Pathway	Cellular senescence; Ras signaling pathway; Leukocyte transendothelial migration; Rap1 signaling pathway
Research Area	Cell Biology
Tissue Specificity	Widely expressed. Frequently down-regulated in lung tumor cell lines and primary lung tumors.
Weight	56.815kD

Stotage Note	Repeated freezing and thawing is not recommended. Store working aliquots at 4℃ for up to one week.
Buffer	Tris-based buffer，50% glycerol
Purity	Greater than 90% as determined by SDS-PAGE.
Storage	The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Storage Buffer	Tris-based buffer,50% glycerol

Immunogen Species	Homo Sapiens (Human)

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SKU	Supplier No.	Size	Your price	Quantity
BHP10503753	CSB-EP819906HU	1mg	$2466		Add to Cart
BHP10503753	CSB-EP819906HU	100ug	$578		Add to Cart
BHP10503753	CSB-EP819906HU	20ug	$306		Add to Cart

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