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Home / Proteins & Peptide

Recombinant Human R-Spondin 1/RSPO1 Protein (aa 1-146, His Tag)(Active)

SKU : BHP10302915

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Elabscience Biotechnology Co.,Ltd

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Mfr.No.	PKSH031268
Description	A DNA sequence encoding the amino acids (Met 1-Ala 146) of human RSPO1 (NP_001033722.1) was expressed, fused with a polyhistidine tag at the C-terminus.
Alternative Names	RSPO1; R-spondin1; RP11-566C13.1; CRISTIN3; FLJ40906; RSPO Rspo1; R-spondin; Rspondin; RP23-325M14.2; Roof plate-specific spondin-1
Reconstitution	Please refer to the printed manual for detailed information.
Background	RSPO1 gene is a member of the R-spondin family. It encodes RSPO1 which is known as a secreted activator protein with two cystein-rich, furin-like domains and one thrombospondin type 1 domain. In mice, RSPO1 induces the rapid onset of crypt cell proliferation and increases intestinal epithelial healing, providing a protective effect against chemotherapy-induced adverse effects. This protein is an activator of the beta-catenin signaling cascade, leading to TCF-dependent gene activation. RSPO1 acts both in the canonical Wnt/beta-catenin-dependent pathway and in non-canonical Wnt signaling pathway, probably by acting as an inhibitor of ZNRF3, an important regulator of the Wnt signaling pathway. It also acts as a ligand for frizzled FZD8 and LRP6.
Reactivity	Human
Tag	C-His
Formulation	Lyophilized from sterile PBS, pH 7.4
Host	HEK293 Cells
Accession Number	NP_001033722.1
Endotoxin Level	< 1.0 EU per ug as determined by the LAL method.
Bioactivity	Measured by its ability to bind recombinant mouse CD36 in a functional ELISA.
Mol Weight	14 kDa
Mw(kda)	14 kDa

Sequence Info	Met 1-Ala 146

Shipping	This product is provided as lyophilized powder which is shipped with ice packs.
Stotage Note	Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
Purity	> 98 % as determined by reducing SDS-PAGE.

Product Manual	Data Sheet

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SKU	Supplier No.	Size	Your price	Quantity
BHP10302915	PKSH031268	100ug	$828		Add to Cart
BHP10302915	PKSH031268	1mg	-		Add to Cart

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