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Home / Proteins & Peptide

Recombinant Human PTGS2/COX2/PGHS-2 Protein (His Tag)

SKU : BHP10302845

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Elabscience Biotechnology Co.,Ltd

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Mfr.No.	PKSH030929
Description	A DNA sequence encoding the human PTGS2 (NP_000954.1) (Met 1-Leu 604) was fused with a polyhistidine tag at the C-terminus.
Alternative Names	COX-2;COX2;GRIPGHS;hCox-2;PGG/HS;PGHS-2;PHS-2
Reconstitution	Please refer to the printed manual for detailed information.
Background	PTGS2, also known as COX-2, is s component of Prostaglandin-endoperoxide synthase (PTGS). PTGS, also known as cyclooxygenase, is the key enzyme in prostaglandin biosynthesis, and acts both as a dioxygenase and as a peroxidase. There are two isozymes of PTGS: a constitutive PTGS1 and an inducible PTGS2, which differ in their regulation of expression and tissue distribution. PTGS2 is over expressed in many cancers. The overexpression of PTGS2 along with increased angiogenesis and GLUT-1 expression is significantly associated with gallbladder carcinomas. Furthermore the product of COX-2, PGH2 is converted by prostaglandin E2 synthase into PGE2, which in turn can stimulate cancer progression. Consequently inhibiting COX-2 may have benefit in the prevention and treatment of these types of cancer. PTGS2 is regulated by specific stimulatory events, suggesting that it is responsible for the prostanoid biosynthesis involved in inflammation and mitogenesis. It mediates the formation of prostaglandins from arachidonate and may have a role as a major mediator of inflammation and/or a role for prostanoid signaling in activity-dependent plasticity.
Reactivity	Human
Tag	C-His
Formulation	Lyophilized from sterile 50mM Tris, 100mM NaCl, 0.5mM PMSF, 10% glycerol, pH 8.0
Host	Baculovirus-Insect Cells
Accession Number	NP_000954.1
Endotoxin Level	< 1.0 EU per ug as determined by the LAL method.
Mol Weight	68.5 kDa
Mw(kda)	68.5 kDa

Sequence Info	Met 1-Leu 604

Shipping	This product is provided as lyophilized powder which is shipped with ice packs.
Stotage Note	Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
Purity	> 95 % as determined by reducing SDS-PAGE.

Product Manual	Data Sheet

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SKU	Supplier No.	Size	Your price	Quantity
BHP10302845	PKSH030929	50ug	$732		Add to Cart

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