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Home / Proteins & Peptide

Recombinant Human Protein-tyrosine phosphatase mitochondrial 1(PTPMT1)

SKU : BHP10501412

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CUSABIO TECHONOLOGY LLC

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Mfr.No.	CSB-EP819889HU
Alternative Names	PTEN-like phosphatasePhosphoinositide lipid phosphataseProtein-tyrosine phosphatase mitochondrial 1 (EC:3.1.3.16, EC:3.1.3.48)
Tag	N-terminal 6xHis-SUMO-tagged
Regulatory	RUO
Relevance	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG). PGP is an essential intermediate in the biosynthetic pathway of cardiolipin, a mitochondrial-specific phospholipid regulating the mbrane integrity and activities of the organelle. Has also been shown to display phosphatase activity toward phosphoprotein substrates, specifically mediates dephosphorylation of mitochondrial proteins, thereby playing an essential role in ATP production. Has probably a preference for proteins phosphorylated on Ser and/or Thr residues compared to proteins phosphorylated on Tyr residues. Probably involved in regulation of insulin secretion in pancreatic beta cells .
Source	E.coli
Notes	Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Expression Region	28-201aa
Mol Weight	35.9kDa
Nature	recombinant
Protein Description	Full Length of Mature Protein

Subcellular Location	Mitochondrion inner membrane
Uniprot	Q8WUK0, Q8WUK0
Database Links	HGNC:26965 OMIM:609538 KEGG:hsa:114971 STRING:9606.ENSP00000325958 UniGene:Hs.656205
Function	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG). PGP is an essential intermediate in the biosynthetic pathway of cardiolipin, a mitochondrial-specific phospholipid regulating the membrane integrity and activities of the organelle. Has also been shown to display phosphatase activity toward phosphoprotein substrates, specifically mediates dephosphorylation of mitochondrial proteins, thereby playing an essential role in ATP production. Has probably a preference for proteins phosphorylated on Ser and/or Thr residues compared to proteins phosphorylated on Tyr residues. Probably involved in regulation of insulin secretion in pancreatic beta cells (By similarity).
Protein Families	Protein-tyrosine phosphatase family, Non-receptor class dual specificity subfamily
Research Area	Signal Transduction
Weight	35.9kDa

Stotage Note	Repeated freezing and thawing is not recommended. Store working aliquots at 4℃ for up to one week.
Buffer	Tris-based buffer，50% glycerol
Purity	Greater than 90% as determined by SDS-PAGE.
Storage	The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Storage Buffer	Tris-based buffer,50% glycerol

Immunogen Species	Homo Sapiens (Human)

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SKU	Supplier No.	Size	Your price	Quantity
BHP10501412	CSB-EP819889HU	1mg	$1812		Add to Cart
BHP10501412	CSB-EP819889HU	100ug	$419		Add to Cart
BHP10501412	CSB-EP819889HU	20ug	$224		Add to Cart

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