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Recombinant Human Protein disulfide-isomerase protein(P4HB),partial(Active)

SKU : BHP10500251

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CUSABIO TECHONOLOGY LLC

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Mfr.No.	CSB-AP000091HU
Alternative Names	PDI, Cellular thyroid hormone-binding protein, Prolyl 4-hydroxylase subunit beta, p55, PDI ; Cellular thyroid hormone-binding protein ; Prolyl 4-hydroxylase subunit beta ; p55
Pubmed Id	3034602; 3611107; 2846539; 14702039; 15489334; 1597478; 9150948; 12665801; 2079031; 1286669; 9399589; 3342239; 1699755; 10636893; 11181151; 12485997; 12095988; 12218051; 12218052; 12643545; 15158710; 14592831; 15644496; 17081065; 21269460; 24275569; 25683
Tag	His
Regulatory	RUO
Source	E.coli
Endotoxin Level	Less than 1.0 EU/μg as determined by LAL method.
Bioactivity	Thiol Protein Reductase Activity is 0.001 Δ650nm/ min-2, determined by measuring the turbidity increase at 650 nm due to insulin reduction.The activity is expressed as the ratio of the slope of a linear part of the turbidity curve to the lag time.
Expression Region	19-456aa
Mol Weight	56.6 kDa
Nature	recombinant
Protein Description	Partial

Involvement In Disease	Cole-Carpenter syndrome 1 (CLCRP1)
Subcellular Location	Endoplasmic reticulum, Endoplasmic reticulum lumen, Melanosome, Cell membrane, Peripheral membrane protein
Uniprot	P07237, P07237
Database Links	HGNC:8548 OMIM:112240 KEGG:hsa:5034 STRING:9606.ENSP00000327801 UniGene:Hs.464336
Function	This multifunctional protein catalyzes the formation, breakage and rearrangement of disulfide bonds. At the cell surface, seems to act as a reductase that cleaves disulfide bonds of proteins attached to the cell. May therefore cause structural modifications of exofacial proteins. Inside the cell, seems to form/rearrange disulfide bonds of nascent proteins. At high concentrations, functions as a chaperone that inhibits aggregation of misfolded proteins. At low concentrations, facilitates aggregation (anti-chaperone activity). May be involved with other chaperones in the structural modification of the TG precursor in hormone biogenesis. Also acts a structural subunit of various enzymes such as prolyl 4-hydroxylase and microsomal triacylglycerol transfer protein MTTP. Receptor for LGALS9; the interaction retains P4HB at the cell surface of Th2 T helper cells, increasing disulfide reductase activity at the plasma membrane, altering the plasma membrane redox state and enhancing cell migration
Pathway	Protein processing in endoplasmic reticulum; ER Stress pathway
Protein Families	Protein disulfide isomerase family
Research Area	Signal Transduction
Weight	56.6 kDa

Buffer	0.2 µm filtered PBS, pH 7.0,lyophilized
Purity	>95% as determined by SDS-PAGE and HPLC.
Storage Buffer	0.2 μm filtered PBS, pH 7.0 ,lyophilized

Immunogen Species	Homo Sapiens (Human)

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SKU	Supplier No.	Size	Your price	Quantity
BHP10500251	CSB-AP000091HU	500ug	$1158		Add to Cart
BHP10500251	CSB-AP000091HU	100ug	$516		Add to Cart

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