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Home / Proteins & Peptide

Recombinant Human Probable methylthioribulose-1-phosphate dehydratase(APIP)

SKU : BHP10503757

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CUSABIO TECHONOLOGY LLC

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Mfr.No.	CSB-EP839332HU
Alternative Names	APAF1-interacting protein
Tag	N-terminal GST-tagged
Regulatory	RUO
Relevance	Catalyzes the dehydration of methylthioribulose-1-phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P). Functions in the methionine salvage pathway, which plays a key role in cancer, apoptosis, microbial proliferation and inflammation. May inhibit the CASP1-related inflammatory response (pyroptosis), the CASP9-dependent apoptotic pathway and the cytochrome c-dependent and APAF1-mediated cell death.
Source	E.coli
Abbreviation	APIP
Notes	Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Protein Name	Recommended name: Probable methylthioribulose-1-phosphate dehydratase; Short name= MTRu-1-P dehydratase; EC= 4.2.1.109; Alternative name(s): APAF1-interacting protein
Expression Region	1-242aa
Mol Weight	54.1kDa
Nature	recombinant
Protein Description	Full Length

Subcellular Location	Cytoplasm
Uniprot	Q96GX9, Q96GX9
Database Links	HGNC:17581 OMIM:612491 KEGG:hsa:51074 STRING:9606.ENSP00000379133 UniGene:Hs.447794
Function	Catalyzes the dehydration of methylthioribulose-1-phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P). Functions in the methionine salvage pathway, which plays a key role in cancer, apoptosis, microbial proliferation and inflammation. May inhibit the CASP1-related inflammatory response (pyroptosis), the CASP9-dependent apoptotic pathway and the cytochrome c-dependent and APAF1-mediated cell death.
Protein Families	Aldolase class II family, MtnB subfamily
Research Area	Cell Biology
Tissue Specificity	Isoform 1 is ubiquitously expressed. Isoform 2 is expressed at lower levels and detected in heart, brain, pancreas, liver, placenta, skeletal muscle and kidney.
Weight	54.262kD

Stotage Note	Repeated freezing and thawing is not recommended. Store working aliquots at 4℃ for up to one week.
Buffer	Tris-based buffer，50% glycerol
Purity	Greater than 90% as determined by SDS-PAGE.
Storage	The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Storage Buffer	Tris-based buffer,50% glycerol

Immunogen Species	Homo Sapiens (Human)

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SKU	Supplier No.	Size	Your price	Quantity
BHP10503757	CSB-EP839332HU	1mg	$1812		Add to Cart
BHP10503757	CSB-EP839332HU	100ug	$419		Add to Cart
BHP10503757	CSB-EP839332HU	20ug	$224		Add to Cart

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