Recombinant Human Pro-neuregulin-3, membrane-bound isoform(NRG3),partial

Mfr.No.	CSB-EP016079HU
Alternative Names	Pro-NRG3
Tag	N-terminal 6xHis-SUMO-tagged
Regulatory	RUO
Relevance	Direct ligand for the ERBB4 tyrosine kinase receptor. Binding results in ligand-stimulated tyrosine phosphorylation and activation of the receptor. Does not bind to the EGF receptor, ERBB2 or ERBB3 receptors. May be a survival factor for oligodendrocytes
Source	E.coli
Notes	Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Expression Region	1-360aa
Mol Weight	53.8kDa
Nature	recombinant
Protein Description	Partial

Subcellular Location	Pro-neuregulin-3, membrane-bound isoform: Cell membrane, Single-pass type I membrane protein, Note=Does not seem to be active, SUBCELLULAR LOCATION: Neuregulin-3: Secreted, SUBCELLULAR LOCATION: Isoform 3: Cell membrane, Single-pass type I membrane protein
Uniprot	P56975, P56975
Database Links	HGNC:7999 OMIM:605533 KEGG:hsa:10718 STRING:9606.ENSP00000361214 UniGene:Hs.125119
Function	Direct ligand for the ERBB4 tyrosine kinase receptor. Binding results in ligand-stimulated tyrosine phosphorylation and activation of the receptor. Does not bind to the EGF receptor, ERBB2 or ERBB3 receptors. May be a survival factor for oligodendrocytes.
Pathway	ErbB signaling pathway
Protein Families	Neuregulin family
Research Area	Cancer
Tissue Specificity	Highly expressed in most regions of the brain with the exception of corpus callosum. Expressed at lower level in testis. Not detected in heart, placenta, lung, liver, skeletal muscle, kidney, pancreas, spleen, thymus, prostate, ovary, small intestine, col
Weight	53.76kDa

Stotage Note	Repeated freezing and thawing is not recommended. Store working aliquots at 4℃ for up to one week.
Buffer	Tris-based buffer，50% glycerol
Purity	Greater than 90% as determined by SDS-PAGE.
Storage	The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Storage Buffer	Tris-based buffer,50% glycerol